Meningococcal serogroup C immunogenicity, antibody persistence and memory B-cells induced by the monovalent meningococcal serogroup C versus quadrivalent meningococcal serogroup ACWY conjugate booster vaccine: A randomized controlled trial.
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Authors
van Ravenhorst, Mariëtte Bvan der Klis, Fiona R M
van Rooijen, Debbie M
Knol, Mirjam J
Stoof, Susanne P
Sanders, Elisabeth A M
Berbers, Guy A M
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en
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Meningococcal serogroup C immunogenicity, antibody persistence and memory B-cells induced by the monovalent meningococcal serogroup C versus quadrivalent meningococcal serogroup ACWY conjugate booster vaccine: A randomized controlled trial.Published in
Vaccine 2017, 35(36):4745-52Publiekssamenvatting
Adolescents are considered the key transmitters of meningococci in the population. Meningococcal serogroup C (MenC) antibody levels wane rapidly after MenC conjugate vaccination in young children, leaving adolescents with low antibody levels. In this study, we compared MenC immune responses after booster vaccination in adolescence with either tetanus toxoid conjugated MenC (MenC-TT) or MenACWY (MenACWY-TT) vaccine, and aimed to establish an optimal age for this booster.PMID
28668575ae974a485f413a2113503eed53cd6c53
10.1016/j.vaccine.2017.06.053
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