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dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorBéraud, Virginie
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorCayssials, Valerie
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorEriksen, Anne K
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorAffret, Aurélie
dc.contributor.authorKatzke, Verena
dc.contributor.authorKühn, Tilman
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorValanou, Elisavet
dc.contributor.authorKarakatsani, Anna
dc.contributor.authorMasala, Giovanna
dc.contributor.authorGrioni, Sara
dc.contributor.authorSantucci de Magistris, Maria
dc.contributor.authorTumino, Rosario
dc.contributor.authorRicceri, Fulvio
dc.contributor.authorSkeie, Guri
dc.contributor.authorParr, Christine L
dc.contributor.authorMerino, Susana
dc.contributor.authorSalamanca-Fernández, Elena
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorAmiano, Pilar
dc.contributor.authorAlmquist, Martin
dc.contributor.authorDrake, Isabel
dc.contributor.authorHennings, Joakim
dc.contributor.authorSandström, Maria
dc.contributor.authorBueno-de-Mesquita, H B As
dc.contributor.authorPeeters, Petra H
dc.contributor.authorKhaw, Kay-Thee
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorPerez-Cornago, Aurora
dc.contributor.authorAune, Dagfinn
dc.contributor.authorRiboli, Elio
dc.contributor.authorSlimani, Nadia
dc.contributor.authorScalbert, Augustin
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorAgudo, Antonio
dc.contributor.authorRinaldi, Sabina
dc.date.accessioned2018-01-03T12:45:06Z
dc.date.available2018-01-03T12:45:06Z
dc.date.issued2018-02-01
dc.identifier.citationConsumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. 2018, 142 (3):449-459 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid28688112
dc.identifier.doi10.1002/ijc.30880
dc.identifier.urihttp://hdl.handle.net/10029/620992
dc.description.abstractFruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68-1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69-1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79-1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98-1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshCohort Studies
dc.subject.meshDiet
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshFruit
dc.subject.meshFruit and Vegetable Juices
dc.subject.meshHealthy Diet
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshProspective Studies
dc.subject.meshThyroid Neoplasms
dc.subject.meshVegetables
dc.titleConsumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2018, 142(3):449-459en
html.description.abstractFruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68-1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69-1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79-1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98-1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.


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