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    Anal HPV 16 and 18 viral load: A comparison between HIV-negative and -positive MSM and association with persistence.

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    Authors
    Marra, Elske
    King, Audrey
    van Logchem, Elske
    van der Weele, Pascal
    Mooij, Sofie H
    Heijman, Titia
    Meijer, Chris J L M
    Verhagen, Dominique W M
    van der Sande, Marianne A B
    Schim van der Loeff, Maarten F
    Type
    Article
    Language
    en
    
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    Title
    Anal HPV 16 and 18 viral load: A comparison between HIV-negative and -positive MSM and association with persistence.
    Published in
    J Med Virol 2018, 90(1):76-83
    Publiekssamenvatting
    Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and -positive men who have sex with men (MSM)? MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and HPV18 load was determined with a type specific quantitative (q)PCR, and compared between HIV-negative and -positive men using ranksum test. Persistence was defined as ≥3 positive samples for the same HPV-type. Determinants of persistent HPV16/18 infection and its association with HPV16/18 load were assessed with logistic regression. Of 777 recruited MSM, 54 and 22 HIV negative men were HPV16 and HPV18 positive at baseline, and 64 and 39 HIV-positive MSM. The geometric mean titer (GMT) of HPV16 was 19.6 (95%CI 10.1-38.0) and of HPV18 8.6 (95%CI 2.7-27.5) DNA copies/human cell. HPV16 and HPV18 load did not differ significantly between HIV-negative and -positive MSM (P = 0.7; P = 0.8, respectively). In multivariable analyses HPV16 load was an independent determinant of HPV16 persistence (OR 1.8, 95%CI 1.3-2.4). No difference in anal HPV viral load was found between HIV-positive and HIV-negative MSM. HPV 16/18 viral load is an independent determinant of type-specific persistence.
    DOI
    10.1002/jmv.24898
    PMID
    28700080
    URI
    http://hdl.handle.net/10029/621003
    ae974a485f413a2113503eed53cd6c53
    10.1002/jmv.24898
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