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dc.contributor.authorBotteri, E
dc.contributor.authorFerrari, P
dc.contributor.authorRoswall, N
dc.contributor.authorTjønneland, A
dc.contributor.authorHjartåker, A
dc.contributor.authorHuerta, J M
dc.contributor.authorFortner, R T
dc.contributor.authorTrichopoulou, A
dc.contributor.authorKarakatsani, A
dc.contributor.authorLa Vecchia, C
dc.contributor.authorPala, V
dc.contributor.authorPerez-Cornago, A
dc.contributor.authorSonestedt, E
dc.contributor.authorLiedberg, F
dc.contributor.authorOvervad, K
dc.contributor.authorSánchez, M J
dc.contributor.authorGram, I T
dc.contributor.authorStepien, M
dc.contributor.authorTrijsburg, L
dc.contributor.authorBörje, L
dc.contributor.authorJohansson, M
dc.contributor.authorKühn, T
dc.contributor.authorPanico, S
dc.contributor.authorTumino, R
dc.contributor.authorBueno-de-Mesquita, H B As
dc.contributor.authorWeiderpass, E
dc.date.accessioned2018-01-04T13:01:45Z
dc.date.available2018-01-04T13:01:45Z
dc.date.issued2017-11-15
dc.identifier.citationAlcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort. 2017, 141 (10):1963-1970 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid28722206
dc.identifier.doi10.1002/ijc.30894
dc.identifier.urihttp://hdl.handle.net/10029/621023
dc.description.abstractFindings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00-1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01-1.07). Men reporting high baseline intakes of alcohol (>96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03-2.40) compared to those reporting moderate intakes (<6 g/day), but no dose-response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (>6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits > 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01-1.91) and smokers (1.39; 95% CI 1.01-1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.subject.meshAlcohol Drinking
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMeta-Analysis as Topic
dc.subject.meshMiddle Aged
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshRisk Factors
dc.subject.meshUnited Kingdom
dc.subject.meshUrinary Bladder Neoplasms
dc.titleAlcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2017, 141(10):1963-70en
html.description.abstractFindings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits). Baseline alcohol intake was associated with a statistically nonsignificant increased risk of UCC (HR 1.03; 95% confidence interval (CI) 1.00-1.06 for each additional 12 g/day). HR in smokers was 1.04 (95% CI 1.01-1.07). Men reporting high baseline intakes of alcohol (>96 g/day) had an increased risk of UCC (HR 1.57; 95% CI 1.03-2.40) compared to those reporting moderate intakes (<6 g/day), but no dose-response relationship emerged. In men, an increased risk of aggressive forms of UCC was observed even at lower doses (>6 to 24 g/day). Average lifelong alcohol intake was not associated with the risk of UCC, however intakes of spirits > 24 g/day were associated with an increased risk of UCC in men (1.38; 95% CI 1.01-1.91) and smokers (1.39; 95% CI 1.01-1.92), compared to moderate intakes. We found no association between alcohol and UCC in women and never smokers. In conclusion, we observed some associations between alcohol and UCC in men and in smokers, possibly because of residual confounding by tobacco smoking.


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