Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Baggen, JimHurdiss, Daniel L
Zocher, Georg
Mistry, Nitesh
Roberts, Richard W
Slager, Jasper J
Guo, Hongbo
van Vliet, Arno L W
Wahedi, Maryam
Benschop, Kimberley
Duizer, Erwin
de Haan, Cornelis A M
de Vries, Erik
Casasnovas, José M
de Groot, Raoul J
Arnberg, Niklas
Stehle, Thilo
Ranson, Neil A
Thibaut, Hendrik Jan
van Kuppeveld, Frank J M
Language
en
Metadata
Show full item recordTitle
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus.Published in
Proc Natl Acad Sci U.S.A. 2018; advance online publication (ahead of print)Publiekssamenvatting
Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in 1970 a pathogenic "variant" (CV-A24v) emerged, which is now the main cause of AHC. Initially, this variant circulated only in Southeast Asia, but it later spread worldwide, accounting for numerous AHC outbreaks and two pandemics. While both CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for reasons that are yet unknown. Since receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoire and establish whether changes in receptor preference have led to the increased pathogenicity and rapid spread of CV-A24v. Here, we identify ICAM-1 as an essential receptor for both AHC-causing and non-AHC strains. We provide a high-resolution cryo-EM structure of a virus-ICAM-1 complex, which revealed critical ICAM-1-binding residues. These data could help identify a possible conserved mode of receptor engagement among ICAM-1-binding enteroviruses and rhinoviruses. Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptation enhances the capacity of CV-A24v to bind sialic acid. Our data elucidate the CV-A24v receptor repertoire and point to a role of enhanced receptor engagement in the adaptation to the eye, possibly enabling pandemic spread.PMID
29284752ae974a485f413a2113503eed53cd6c53
10.1073/pnas.1713284115
Scopus Count
Collections
Related articles
- [Molecular Identification and Phylogenetic Analyses of Coxsackievirus A24v Causing an Outbreak of Acute Hemorrhagic Conjunctivitis in Jiangxi, China, in 2010].
- Authors: Yan D, Xiong Y, Zhang Y, Yang Q, Zhang S, Gong T, Zhu T, Wang D, Zhu H, Xu W
- Issue date: 2015 May
- Molecular identification and phylogenetic study of coxsackievirus A24 variant isolated from an outbreak of acute hemorrhagic conjunctivitis in India in 2010.
- Authors: Shukla D, Kumar A, Srivastava S, Dhole TN
- Issue date: 2013 Mar
- Re-emergence of a coxsackievirus A24 variant causing acute hemorrhagic conjunctivitis in Brazil from 2017 to 2018.
- Authors: Sousa IP Jr, Burlandy FM, Ferreira JL, Alves JCS, Sousa-Júnior EC, Tavares FN, da Silva EE
- Issue date: 2019 Apr
- Complete genome sequence of a coxsackievirus type A24 variant causing an outbreak of acute haemorrhagic conjunctivitis in southeastern Mexico in 2017.
- Authors: Fragoso-Fonseca DE, Escobar-Escamilla N, Rodríguez-Maldonado AP, Barrera-Badillo G, Garcés-Ayala F, Mendieta-Condado E, González-Durán E, Puerto FI, Hernández-Rivas L, López-Martínez I, Díaz-Quiñonez JA, Ramírez-González JE
- Issue date: 2020 Apr
- Molecular characterization and phylogenetic study of coxsackievirus A24v causing outbreaks of acute hemorrhagic conjunctivitis (AHC) in Brazil.
- Authors: Tavares FN, Campos Rde M, Burlandy FM, Fontella R, de Melo MM, da Costa EV, da Silva EE
- Issue date: 2011