Skin sensitisation quantitative risk assessment (QRA) based on aggregate dermal exposure to methylisothiazolinone in personal care and household cleaning products.
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TitleSkin sensitisation quantitative risk assessment (QRA) based on aggregate dermal exposure to methylisothiazolinone in personal care and household cleaning products.
Published inFood Chem Toxicol 2018: advance online publication (ahead of print)
PubliekssamenvattingContact allergy to preservatives is an important public health problem. Ideally, new substances should be evaluated for the risk on skin sensitization before market entry, for example by using a quantitative risk assessment (QRA) as developed for fragrances. As a proof-of-concept, this QRA was applied to the preservative methylisothiazolinone (MI), a common cause of contact allergy. MI is used in different consumer products, including personal care products (PCPs) and household cleaning products (HCPs). Aggregate exposure to MI in PCPs and HCPs was therefore assessed with the Probabilistic Aggregated Consumer Exposure Model (PACEM). Two exposure scenarios were evaluated: scenario 1 calculated aggregate exposure on actual MI product concentrations before the restricted use in PCPs and scenario 2 calculated aggregate exposure using the restrictions for MI in PCPs. The QRA for MI showed that in scenarios 1 and 2, the proportion of the population at risk for skin sensitisation is 0.7% and 0.5%, respectively. The restricted use of MI in PCPs does not seem very effective in lowering the risk on skin sensitization. To conclude, it is important to consider aggregate exposure from the most important consumer products into consideration in the risk assessment.
- Occurrence and concentrations of isothiazolinones in detergents and cosmetics in Switzerland.
- Authors: Garcia-Hidalgo E, Sottas V, von Goetz N, Hauri U, Bogdal C, Hungerbühler K
- Issue date: 2017 Feb
- Aggregate consumer exposure to isothiazolinones via household care and personal care products: Probabilistic modelling and benzisothiazolinone risk assessment.
- Authors: Garcia-Hidalgo E, Schneider D, von Goetz N, Delmaar C, Siegrist M, Hungerbühler K
- Issue date: 2018 Sep
- Application of in vitro skin penetration measurements to confirm and refine the quantitative skin sensitization risk assessment of methylisothiazolinone.
- Authors: Rothe H, Ryan CA, Page L, Vinall J, Goebel C, Scheffler H, Toner F, Roper C, Kern PS
- Issue date: 2017 Dec
- Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only).
- Authors: Scientific Committee Of Consumer Safety, Giménez-Arnau AM
- Issue date: 2016 Apr
- Risk Assessment of the Skin Sensitization Induction Potential of Kathon CG in Rinse-off and Leave-on Personal Care and Cosmetic Products.
- Authors: Towle KM, Drechsel DA, Warshaw EM, Fung ES, Novick RM, Paustenbach DJ, Monnot AD
- Issue date: 2018 May/Jun