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    Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM.

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    Authors
    van der Heiden, Marieke
    van Ravenhorst, Mariette B
    Bogaard, Marjan
    Boots, Annemieke M H
    Berbers, Guy A M
    Buisman, Anne-Marie
    Language
    en
    
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    Title
    Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM.
    Published in
    Expl Gerontol 2018; 105:101-8
    Publiekssamenvatting
    Successful vaccination of elderly persons is often hampered by immunological ageing, leaving part of the elderly population vulnerable for infectious diseases. As an alternative, timely vaccinations might be administered at middle-age, before reaching old age. Studies evaluating the immunological fitness of middle-aged adults are warranted. In this study we compared the immunogenicity of a primary meningococcal vaccination in Dutch middle-aged adults with that in adolescents, in order to gain knowledge on the early signs of immune ageing.
    DOI
    10.1016/j.exger.2017.12.014
    PMID
    29287771
    URI
    http://hdl.handle.net/10029/621040
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.exger.2017.12.014
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