Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.
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Authors
Carayol, MarionLeitzmann, Michael F
Ferrari, Pietro
Zamora-Ros, Raul
Achaintre, David
Stepien, Magdalena
Schmidt, Julie A
Travis, Ruth C
Overvad, Kim
Tjønneland, Anne
Hansen, Louise
Kaaks, Rudolf
Kühn, Tilman
Boeing, Heiner
Bachlechner, Ursula
Trichopoulou, Antonia
Bamia, Christina
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Quirós, J Ramón
Sánchez-Cantalejo, Emilio
Huerta, José María
Ardanaz, Eva
Arriola, Larraitz
Agudo, Antonio
Nilsson, Jan
Melander, Olle
Bueno-de-Mesquita, Bas
Peeters, Petra H
Wareham, Nick
Khaw, Kay-Tee
Jenab, Mazda
Key, Timothy J
Scalbert, Augustin
Rinaldi, Sabina
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ArticleLanguage
en
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Show full item recordTitle
Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort.Published in
J Proteome Res 2017, 16(9):3137-46Publiekssamenvatting
Metabolomics is now widely used to characterize metabolic phenotypes associated with lifestyle risk factors such as obesity. The objective of the present study was to explore the associations of body mass index (BMI) with 145 metabolites measured in blood samples in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Metabolites were measured in blood from 392 men from the Oxford (UK) cohort (EPIC-Oxford) and in 327 control subjects who were part of a nested case-control study on hepatobiliary carcinomas (EPIC-Hepatobiliary). Measured metabolites included amino acids, acylcarnitines, hexoses, biogenic amines, phosphatidylcholines, and sphingomyelins. Linear regression models controlled for potential confounders and multiple testing were run to evaluate the associations of metabolite concentrations with BMI. 40 and 45 individual metabolites showed significant differences according to BMI variations, in the EPIC-Oxford and EPIC-Hepatobiliary subcohorts, respectively. Twenty two individual metabolites (kynurenine, one sphingomyelin, glutamate and 19 phosphatidylcholines) were associated with BMI in both subcohorts. The present findings provide additional knowledge on blood metabolic signatures of BMI in European adults, which may help identify mechanisms mediating the relationship of BMI with obesity-related diseases.PMID
28758405ae974a485f413a2113503eed53cd6c53
10.1021/acs.jproteome.6b01062
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