Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
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Bello González, Teresita D J
de Steenhuijsen Piters, Wouter A A
Bayjanov, Jumamurat R
Majoor, Eline A M
Braat, Johanna C
van Mourik, Maaike S M
Oostdijk, Evelien A N
Willems, Rob J L
Bonten, Marc J M
van Passel, Mark W J
van Schaik, Willem
MetadataShow full item record
TitleComparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
Published inMicrobiome 2017, 5(1):188
PubliekssamenvattingThe gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut microbiota remains largely unknown. Here, we characterize the composition of the gut microbiota and its antimicrobial resistance genes ("the resistome") of ICU patients during SDD and of healthy subjects.
- Effects of selective digestive decontamination (SDD) on the gut resistome.
- Authors: Buelow E, Gonzalez TB, Versluis D, Oostdijk EA, Ogilvie LA, van Mourik MS, Oosterink E, van Passel MW, Smidt H, D'Andrea MM, de Been M, Jones BV, Willems RJ, Bonten MJ, van Schaik W
- Issue date: 2014 Aug
- Carriage of antibiotic-resistant Gram-negative bacteria after discontinuation of selective decontamination of the digestive tract (SDD) or selective oropharyngeal decontamination (SOD).
- Authors: de Jonge E, de Wilde RBP, Juffermans NP, Oostdijk EAN, Bernards AT, van Essen EHR, Kuijper EJ, Visser CE, Kesecioglu J, Bonten MJM
- Issue date: 2018 Sep 29
- Prenatal and postnatal antibiotic exposure influences the gut microbiota of preterm infants in neonatal intensive care units.
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- Issue date: 2018 Mar 19
- Selective oropharyngeal decontamination versus selective digestive decontamination in critically ill patients: a meta-analysis of randomized controlled trials.
- Authors: Zhao D, Song J, Gao X, Gao F, Wu Y, Lu Y, Hou K
- Issue date: 2015
- Probiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner.
- Authors: Montassier E, Valdés-Mas R, Batard E, Zmora N, Dori-Bachash M, Suez J, Elinav E
- Issue date: 2021 Aug