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    Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.

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    Authors
    Buelow, Elena
    Bello González, Teresita D J
    Fuentes, Susana
    de Steenhuijsen Piters, Wouter A A
    Lahti, Leo
    Bayjanov, Jumamurat R
    Majoor, Eline A M
    Braat, Johanna C
    van Mourik, Maaike S M
    Oostdijk, Evelien A N
    Willems, Rob J L
    Bonten, Marc J M
    van Passel, Mark W J
    Smidt, Hauke
    van Schaik, Willem
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    Type
    Article
    Language
    en
    
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    Title
    Comparative gut microbiota and resistome profiling of intensive care patients receiving selective digestive tract decontamination and healthy subjects.
    Published in
    Microbiome 2017, 5(1):188
    Publiekssamenvatting
    The gut microbiota is a reservoir of opportunistic pathogens that can cause life-threatening infections in critically ill patients during their stay in an intensive care unit (ICU). To suppress gut colonization with opportunistic pathogens, a prophylactic antibiotic regimen, termed "selective decontamination of the digestive tract" (SDD), is used in some countries where it improves clinical outcome in ICU patients. Yet, the impact of ICU hospitalization and SDD on the gut microbiota remains largely unknown. Here, we characterize the composition of the gut microbiota and its antimicrobial resistance genes ("the resistome") of ICU patients during SDD and of healthy subjects.
    DOI
    10.1186/s40168-017-0309-z
    PMID
    28803549
    URI
    http://hdl.handle.net/10029/621069
    ae974a485f413a2113503eed53cd6c53
    10.1186/s40168-017-0309-z
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