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    Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

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    Authors
    Hullmann, Maja
    Albrecht, Catrin
    van Berlo, Damiën
    Gerlofs-Nijland, Miriam E
    Wahle, Tina
    Boots, Agnes W
    Krutmann, Jean
    Cassee, Flemming R
    Bayer, Thomas A
    Schins, Roel P F
    Type
    Article
    Language
    en
    
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    Title
    Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
    Published in
    Part Fibre toxicol 2017, 14(1):35
    Publiekssamenvatting
    Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.
    DOI
    10.1186/s12989-017-0213-5
    PMID
    28854940
    URI
    http://hdl.handle.net/10029/621086
    ae974a485f413a2113503eed53cd6c53
    10.1186/s12989-017-0213-5
    Scopus Count
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