Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
van Berlo, Damiën
Gerlofs-Nijland, Miriam E
Boots, Agnes W
Cassee, Flemming R
Bayer, Thomas A
Schins, Roel P F
MetadataShow full item record
TitleDiesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Published inPart Fibre toxicol 2017, 14(1):35
PubliekssamenvattingIncreasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.
- Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.
- Authors: Wahle T, Sofranko A, Dekkers S, Miller MR, Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF
- Issue date: 2020 Sep
- Effects of concentrated ambient particles and diesel engine exhaust on allergic airway disease in Brown Norway rats.
- Authors: Harkema JR, Wagner JG, Kaminski NE, Morishita M, Keeler GJ, McDonald JD, Barrett EG, HEI Health Review Committee.
- Issue date: 2009 Nov
- Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain.
- Authors: Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A
- Issue date: 2010 May 17
- Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles.
- Authors: Gerlofs-Nijland ME, Totlandsdal AI, Kilinç E, Boere AJ, Fokkens PH, Leseman DL, Sioutas C, Schwarze PE, Spronk HM, Hadoke PW, Miller MR, Cassee FR
- Issue date: 2010 Dec
- Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer's disease mice.
- Authors: Jew K, Herr D, Wong C, Kennell A, Morris-Schaffer K, Oberdörster G, O'Banion MK, Cory-Slechta DA, Elder A
- Issue date: 2019 Nov 26