Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
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van Berlo, Damiën
Gerlofs-Nijland, Miriam E
Boots, Agnes W
Cassee, Flemming R
Bayer, Thomas A
Schins, Roel P F
MetadataShow full item record
TitleDiesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.
Published inPart Fibre toxicol 2017, 14(1):35
PubliekssamenvattingIncreasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.
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