Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Hullmann, Maja; Albrecht, Catrin; van Berlo, Damiën; Gerlofs-Nijland, Miriam E; Wahle, Tina; Boots, Agnes W; Krutmann, Jean; Cassee, Flemming R; Bayer, Thomas A; Schins, Roel P F

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Authors

Hullmann, Maja
Albrecht, Catrin
van Berlo, Damiën
Gerlofs-Nijland, Miriam E
Wahle, Tina
Boots, Agnes W
Krutmann, Jean
Cassee, Flemming R
Bayer, Thomas A
Schins, Roel P F

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Article

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Title

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Published in

Part Fibre toxicol 2017, 14(1):35

Publiekssamenvatting

Increasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer's Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.