A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
TitleA Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials.
Published inMaterials 2017, 10(9):e1013
PubliekssamenvattingGathering required information in a fast and inexpensive way is essential for assessing the risks of engineered nanomaterials (ENMs). The extension of conventional (quantitative) structure-activity relationships ((Q)SARs) approach to nanotoxicology, i.e., nano-(Q)SARs, is a possible solution. The preliminary attempts of correlating ENMs' characteristics to the biological effects elicited by ENMs highlighted the potential applicability of (Q)SARs in the nanotoxicity field. This review discusses the current knowledge on the development of nano-(Q)SARs for metallic ENMs, on the aspects of data sources, reported nano-(Q)SARs, and mechanistic interpretation. An outlook is given on the further development of this frontier. As concluded, the used experimental data mainly concern the uptake of ENMs by different cell lines and the toxicity of ENMs to cells lines and Escherichia coli. The widely applied techniques of deriving models are linear and non-linear regressions, support vector machine, artificial neural network, k-nearest neighbors, etc. Concluded from the descriptors, surface properties of ENMs are seen as vital for the cellular uptake of ENMs; the capability of releasing ions and surface redox properties of ENMs are of importance for evaluating nanotoxicity. This review aims to present key advances in relevant nano-modeling studies and stimulate future research efforts in this quickly developing field of research.
- Current Knowledge on the Use of Computational Toxicology in Hazard Assessment of Metallic Engineered Nanomaterials.
- Authors: Chen G, Peijnenburg W, Xiao Y, Vijver MG
- Issue date: 2017 Jul 12
- In silico analysis of nanomaterials hazard and risk.
- Authors: Cohen Y, Rallo R, Liu R, Liu HH
- Issue date: 2013 Mar 19
- Literature Review of (Q)SAR Modelling of Nanomaterial Toxicity.
- Authors: Oksel C, Ma CY, Liu JJ, Wilkins T, Wang XZ
- Issue date: 2017
- Current situation on the availability of nanostructure-biological activity data.
- Authors: Oksel C, Ma CY, Wang XZ
- Issue date: 2015
- Nanotoxicity of engineered nanomaterials (ENMs) to environmentally relevant beneficial soil bacteria - a critical review.
- Authors: Lewis RW, Bertsch PM, McNear DH
- Issue date: 2019 Apr