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dc.contributor.authorMcIlvride, Saraid
dc.contributor.authorMushtaq, Aleena
dc.contributor.authorPapacleovoulou, Georgia
dc.contributor.authorHurling, Chloe
dc.contributor.authorSteel, Jennifer
dc.contributor.authorJansen, Eugène
dc.contributor.authorAbu-Hayyeh, Shadi
dc.contributor.authorWilliamson, Catherine
dc.date.accessioned2018-01-09T13:52:25Z
dc.date.available2018-01-09T13:52:25Z
dc.date.issued2017-09-06
dc.identifier.citationA progesterone-brown fat axis is involved in regulating fetal growth. 2017, 7 (1):10671 Sci Repen
dc.identifier.issn2045-2322
dc.identifier.pmid28878263
dc.identifier.doi10.1038/s41598-017-10979-7
dc.identifier.urihttp://hdl.handle.net/10029/621100
dc.description.abstractPregnancy is associated with profound maternal metabolic changes, necessary for the growth and development of the fetus, mediated by reproductive signals acting on metabolic organs. However, the role of brown adipose tissue (BAT) in regulating gestational metabolism is unknown. We show that BAT phenotype is lost in murine pregnancy, while there is a gain of white adipose tissue (WAT)-like features. This is characterised by reduced thermogenic capacity and mitochondrial content, accompanied by increased levels of markers of WAT and lipid accumulation. Surgical ablation of BAT prior to conception caused maternal and fetal hyperlipidemia, and consequently larger fetuses. We show that BAT phenotype is altered from day 5 of gestation, implicating early pregnancy factors, which was confirmed by reduced expression of BAT markers in progesterone challenged oophorectomised mice. Moreover, in vitro data using primary BAT cultures show a direct impact of progesterone on expression of Ucp1. These data demonstrate that progesterone mediates a phenotypic change in BAT, which contributes to the gestational metabolic environment, and thus overall fetal size.
dc.language.isoenen
dc.rightsArchived with thanks to Scientific reportsen
dc.titleA progesterone-brown fat axis is involved in regulating fetal growth.en
dc.typeArticleen
dc.identifier.journalSci Rep 2017, 7(1):10671en
html.description.abstractPregnancy is associated with profound maternal metabolic changes, necessary for the growth and development of the fetus, mediated by reproductive signals acting on metabolic organs. However, the role of brown adipose tissue (BAT) in regulating gestational metabolism is unknown. We show that BAT phenotype is lost in murine pregnancy, while there is a gain of white adipose tissue (WAT)-like features. This is characterised by reduced thermogenic capacity and mitochondrial content, accompanied by increased levels of markers of WAT and lipid accumulation. Surgical ablation of BAT prior to conception caused maternal and fetal hyperlipidemia, and consequently larger fetuses. We show that BAT phenotype is altered from day 5 of gestation, implicating early pregnancy factors, which was confirmed by reduced expression of BAT markers in progesterone challenged oophorectomised mice. Moreover, in vitro data using primary BAT cultures show a direct impact of progesterone on expression of Ucp1. These data demonstrate that progesterone mediates a phenotypic change in BAT, which contributes to the gestational metabolic environment, and thus overall fetal size.


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