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    Mechanisms of bacterial resistance to antimicrobial agents.

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    Authors
    van Duijkeren, Engeline
    Schink, Anne-Kathrin
    Roberts, Marilyn C
    Wang, Yang
    Schwarz, Stefan
    Type
    Article
    Language
    en
    
    Metadata
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    Title
    Mechanisms of bacterial resistance to antimicrobial agents.
    Published in
    Microbiol Spectr 2018; 6(1)
    Publiekssamenvatting
    During the past decades resistance to virtually all antimicrobial agents has been observed in bacteria of animal origin. This chapter describes in detail the mechanisms so far encountered for the various classes of antimicrobial agents. The main mechanisms include enzymatic inactivation by either disintegration or chemical modification of antimicrobial agents, reduced intracellular accumulation by either decreased influx or increased efflux of antimicrobial agents, and modifications at the cellular target sites (i.e., mutational changes, chemical modification, protection, or even replacement of the target sites). Often several mechanisms interact to enhance bacterial resistance to antimicrobial agents. This is a completely revised version of the corresponding chapter in the book Antimicrobial Resistance in Bacteria of Animal Origin published in 2006. New sections have been added for oxazolidinones, polypeptides, mupirocin, ansamycins, fosfomycin, fusidic acid, and streptomycins, and the chapters for the remaining classes of antimicrobial agents have been completely updated to cover the advances in knowledge gained since 2006.
    DOI
    10.1128/microbiolspec.ARBA-0019-2017
    PMID
    29327680
    URI
    http://hdl.handle.net/10029/621153
    ae974a485f413a2113503eed53cd6c53
    10.1128/microbiolspec.ARBA-0019-2017
    Scopus Count
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