Diversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases.
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Authors
Guichelaar, Teunvan Erp, Elisabeth A
Hoeboer, Jeroen
Smits, Noortje A M
van Els, Cécile A C M
Pieren, Daan K J
Luytjes, Willem
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en
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Diversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases.Published in
Dev Comp Immunol 2018; 82:39-48Publiekssamenvatting
Susceptibility and declined resistance to human pathogens like respiratory syncytial virus (RSV) at old age is well represented in the cotton rat (Sigmodon hispidus). Despite providing a preferred model of human infectious diseases, little is known about aging of its adaptive immune system. We aimed to define aging-related changes of the immune system of this species. Concomitantly, we asked whether the rate of immunological alterations may be stratified by physiological aberrations encountered during aging. With increasing age, cotton rats showed reduced frequencies of T cells, impaired induction of antibodies to RSV, higher incidence of aberrations of organs and signs of lipemia. Moreover, old animals expressed high biological heterogeneity, but the age-related reduction of T cell frequency was only observed in those specimens that displayed aberrant organs. Thus, cotton rats show age-related alterations of lymphocytes that can be classified by links with health status.PMID
29305168ae974a485f413a2113503eed53cd6c53
10.1016/j.dci.2017.12.026
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