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dc.contributor.authorGuichelaar, Teun
dc.contributor.authorvan Erp, Elisabeth A
dc.contributor.authorHoeboer, Jeroen
dc.contributor.authorSmits, Noortje A M
dc.contributor.authorvan Els, Cécile A C M
dc.contributor.authorPieren, Daan K J
dc.contributor.authorLuytjes, Willem
dc.date.accessioned2018-01-16T09:45:50Z
dc.date.available2018-01-16T09:45:50Z
dc.date.issued2018-01-02
dc.identifier.citationDiversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases. 2018, 82:39-48 Dev. Comp. Immunol.en
dc.identifier.issn1879-0089
dc.identifier.pmid29305168
dc.identifier.doi10.1016/j.dci.2017.12.026
dc.identifier.urihttp://hdl.handle.net/10029/621172
dc.description.abstractSusceptibility and declined resistance to human pathogens like respiratory syncytial virus (RSV) at old age is well represented in the cotton rat (Sigmodon hispidus). Despite providing a preferred model of human infectious diseases, little is known about aging of its adaptive immune system. We aimed to define aging-related changes of the immune system of this species. Concomitantly, we asked whether the rate of immunological alterations may be stratified by physiological aberrations encountered during aging. With increasing age, cotton rats showed reduced frequencies of T cells, impaired induction of antibodies to RSV, higher incidence of aberrations of organs and signs of lipemia. Moreover, old animals expressed high biological heterogeneity, but the age-related reduction of T cell frequency was only observed in those specimens that displayed aberrant organs. Thus, cotton rats show age-related alterations of lymphocytes that can be classified by links with health status.
dc.language.isoenen
dc.rightsArchived with thanks to Developmental and comparative immunologyen
dc.titleDiversity of aging of the immune system classified in the cotton rat (Sigmodon hispidus) model of human infectious diseases.en
dc.typeArticleen
dc.identifier.journalDev Comp Immunol 2018; 82:39-48en
html.description.abstractSusceptibility and declined resistance to human pathogens like respiratory syncytial virus (RSV) at old age is well represented in the cotton rat (Sigmodon hispidus). Despite providing a preferred model of human infectious diseases, little is known about aging of its adaptive immune system. We aimed to define aging-related changes of the immune system of this species. Concomitantly, we asked whether the rate of immunological alterations may be stratified by physiological aberrations encountered during aging. With increasing age, cotton rats showed reduced frequencies of T cells, impaired induction of antibodies to RSV, higher incidence of aberrations of organs and signs of lipemia. Moreover, old animals expressed high biological heterogeneity, but the age-related reduction of T cell frequency was only observed in those specimens that displayed aberrant organs. Thus, cotton rats show age-related alterations of lymphocytes that can be classified by links with health status.


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