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dc.contributor.authorZuo, Hui
dc.contributor.authorUeland, Per M
dc.contributor.authorMidttun, Øivind
dc.contributor.authorVollset, Stein E
dc.contributor.authorTell, Grethe S
dc.contributor.authorTheofylaktopoulou, Despoina
dc.contributor.authorTravis, Ruth C
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorFournier, Agnès
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorKvaskoff, Marina
dc.contributor.authorBoeing, Heiner
dc.contributor.authorBergmann, Manuela M
dc.contributor.authorFortner, Renée T
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPalli, Domenico
dc.contributor.authorSieri, Sabina
dc.contributor.authorPanico, Salvatore
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorPeeters, Petra H
dc.contributor.authorGrankvist, Kjell
dc.contributor.authorJohansson, Mikael
dc.contributor.authorAgudo, Antonio
dc.contributor.authorGarcia, Jose Ramon Quiros
dc.contributor.authorLarranaga, Nerea
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorChirlaque, Maria Dolores
dc.contributor.authorArdanaz, Eva
dc.contributor.authorChuang, Shu-Chun
dc.contributor.authorGallo, Valentina
dc.contributor.authorBrennan, Paul
dc.contributor.authorJohansson, Mattias
dc.contributor.authorUlvik, Arve
dc.date.accessioned2018-01-16T10:29:36Z
dc.date.available2018-01-16T10:29:36Z
dc.date.issued2018-01-01
dc.identifier.citationResults from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk. 2018, 78 (1):302-308 Cancer Res.en
dc.identifier.issn1538-7445
dc.identifier.pmid29070616
dc.identifier.doi10.1158/0008-5472.CAN-17-1923
dc.identifier.urihttp://hdl.handle.net/10029/621178
dc.description.abstractCirculating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer.Significance: This large cohort study firmly establishes an association between an index of vitamin B6 levels with lung cancer risk. Cancer Res; 78(1); 302-8. ©2017 AACR.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleResults from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk.en
dc.typeArticleen
dc.identifier.journalCancer Res 2018; 78(1):302-8en
html.description.abstractCirculating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P < 0.001]. Additional adjustment for intake of vegetables and fruits and physical activity did not materially affect risk association. The association of PAr with lung cancer risk was similar in both genders but slightly stronger in former smokers and in participants diagnosed with squamous cell carcinoma. This study provides robust evidence that increased vitamin B6 catabolism is independently associated with a higher risk of future lung cancer.Significance: This large cohort study firmly establishes an association between an index of vitamin B6 levels with lung cancer risk. Cancer Res; 78(1); 302-8. ©2017 AACR.


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