Increased colon cancer risk after severe Salmonella infection.

Mughini-Gras, Lapo; Schaapveld, Michael; Kramers, Jolanda; Mooij, Sofie; Neefjes-Borst, E Andra; Pelt, Wilfrid van; Neefjes, Jacques

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Authors

Mughini-Gras, Lapo
Schaapveld, Michael
Kramers, Jolanda
Mooij, Sofie
Neefjes-Borst, E Andra
Pelt, Wilfrid van
Neefjes, Jacques

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Article

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Title

Increased colon cancer risk after severe Salmonella infection.

Published in

Plos One 2018; 13(1):e0189721

Publiekssamenvatting

Colon cancer constitutes one of the most frequent malignancies. Previous studies showed that Salmonella manipulates host cell signaling pathways and that Salmonella Typhimurium infection facilitates colon cancer development in genetically predisposed mice. This epidemiological study examined whether severe Salmonella infection, usually acquired from contaminated food, is associated with increased colon cancer risk in humans.