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AuthorsMiller, Mark R
Raftis, Jennifer B
Langrish, Jeremy P
McLean, Steven G
Connell, Shea P
Vesey, Alex T
Fokkens, Paul H B
Boere, A John F
Campbell, Colin J
Hadoke, Patrick W F
Cassee, Flemming R
Newby, David E
Mills, Nicholas L
MetadataShow full item record
TitleInhaled Nanoparticles Accumulate at Sites of Vascular Disease.
Published inACS Nano 2017; 11(5):4542-52
PubliekssamenvattingThe development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy. Healthy volunteers were exposed to nanoparticles by acute inhalation, followed by repeated sampling of blood and urine. Gold was detected in the blood and urine within 15 min to 24 h after exposure, and was still present 3 months after exposure. Levels were greater following inhalation of 5 nm (primary diameter) particles compared to 30 nm particles. Studies in mice demonstrated the accumulation in the blood and liver following pulmonary exposure to a broader size range of gold nanoparticles (2-200 nm primary diameter), with translocation markedly greater for particles <10 nm diameter. Gold nanoparticles preferentially accumulated in inflammation-rich vascular lesions of fat-fed apolipoproteinE-deficient mice. Furthermore, following inhalation, gold particles could be detected in surgical specimens of carotid artery disease from patients at risk of stroke. Translocation of inhaled nanoparticles into the systemic circulation and accumulation at sites of vascular inflammation provides a direct mechanism that can explain the link between environmental nanoparticles and cardiovascular disease and has major implications for risk management in the use of engineered nanomaterials.
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- Do inhaled carbon nanoparticles translocate directly into the circulation in humans?
- Authors: Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, Macnee W, Millar AM, Donaldson K, Newby DE
- Issue date: 2006 Feb 15
- Age-Dependent Rat Lung Deposition Patterns of Inhaled 20 Nanometer Gold Nanoparticles and their Quantitative Biokinetics in Adult Rats.
- Authors: Kreyling WG, Möller W, Holzwarth U, Hirn S, Wenk A, Schleh C, Schäffler M, Haberl N, Gibson N, Schittny JC
- Issue date: 2018 Aug 28
- Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles.
- Authors: Buckley A, Warren J, Hodgson A, Marczylo T, Ignatyev K, Guo C, Smith R
- Issue date: 2017 Feb 10
- Subchronic inhalation toxicity of gold nanoparticles.
- Authors: Sung JH, Ji JH, Park JD, Song MY, Song KS, Ryu HR, Yoon JU, Jeon KS, Jeong J, Han BS, Chung YH, Chang HK, Lee JH, Kim DW, Kelman BJ, Yu IJ
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