Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.

Nebenzahl-Guimaraes, Hanna; van Laarhoven, Arjan; Farhat, Maha R; Koeken, Valerie A C M; Mandemakers, Jornt J; Zomer, Aldert; van Hijum, Sacha A F T; Netea, Mihai G; Murray, Megan; van Crevel, Reinout; van Soolingen, Dick

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Authors

Nebenzahl-Guimaraes, Hanna
van Laarhoven, Arjan
Farhat, Maha R
Koeken, Valerie A C M
Mandemakers, Jornt J
Zomer, Aldert
van Hijum, Sacha A F T
Netea, Mihai G
Murray, Megan
van Crevel, Reinoutvan Soolingen, Dick

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Title

Transmissible Mycobacterium tuberculosis Strains Share Genetic Markers and Immune Phenotypes.

Published in

Am J Resp Crit Care Med 2017; 195(11):1519-27

Publiekssamenvatting

Successful transmission of tuberculosis depends on the interplay of human behavior, host immune responses, and Mycobacterium tuberculosis virulence factors. Previous studies have been focused on identifying host risk factors associated with increased transmission, but the contribution of specific genetic variations in mycobacterial strains themselves are still unknown.