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dc.contributor.authorWard, Heather A
dc.contributor.authorWark, Petra A
dc.contributor.authorMuller, David C
dc.contributor.authorSteffen, Annika
dc.contributor.authorJohansson, Mattias
dc.contributor.authorNorat, Teresa
dc.contributor.authorGunter, Marc J
dc.contributor.authorOvervad, Kim
dc.contributor.authorDahm, Christina C
dc.contributor.authorHalkjær, Jytte
dc.contributor.authorTjønneland, Anne
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorMesrine, Sylvie
dc.contributor.authorBrennan, Paul
dc.contributor.authorFreisling, Heinz
dc.contributor.authorLi, Kuanrong
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorPanico, Salavatore
dc.contributor.authorGrioni, Sara
dc.contributor.authorTumino, Rosario
dc.contributor.authorVineis, Paolo
dc.contributor.authorPalli, Domenico
dc.contributor.authorPeeters, Petra H M
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAgudo, Antonio
dc.contributor.authorQuirós, Jose Ramón
dc.contributor.authorLarrañaga, Nerea
dc.contributor.authorArdanaz, Eva
dc.contributor.authorHuerta, José María
dc.contributor.authorSánchez, María-José
dc.contributor.authorLaurell, Göran
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorWestin, Ulla
dc.contributor.authorWallström, Peter
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorPearson, Clare
dc.contributor.authorBoeing, Heiner
dc.contributor.authorRiboli, Elio
dc.date.accessioned2018-01-24T11:27:42Z
dc.date.available2018-01-24T11:27:42Z
dc.date.issued2017-06
dc.identifier.citationMeasured Adiposity in Relation to Head and Neck Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. 2017, 26 (6):895-904 Cancer Epidemiol. Biomarkers Prev.en
dc.identifier.issn1538-7755
dc.identifier.pmid28183827
dc.identifier.doi10.1158/1055-9965.EPI-16-0886
dc.identifier.urihttp://hdl.handle.net/10029/621239
dc.description.abstractBackground: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23-2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction = 0.004). Among men, WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21-1.65).Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated.Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence. Cancer Epidemiol Biomarkers Prev; 26(6); 895-904. ©2017 AACR.
dc.language.isoenen
dc.rightsArchived with thanks to Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncologyen
dc.titleMeasured Adiposity in Relation to Head and Neck Cancer Risk in the European Prospective Investigation into Cancer and Nutrition.en
dc.typeArticleen
dc.identifier.journalCancer Epidemiol Biomarkers Prev 2017; 26(6):895-904en
html.description.abstractBackground: Emerging evidence from cohort studies indicates that adiposity is associated with greater incidence of head and neck cancer. However, most studies have used self-reported anthropometry which is prone to error.Methods: Among 363,094 participants in the European Prospective Investigation into Cancer and Nutrition study (EPIC) with measured anthropometry, there were 837 incident cases of head and neck cancer. Head and neck cancer risk was examined in relation to body mass index (BMI) [lean: <22.5 kg/m2, normal weight (reference): 22.5-24.9 kg/m2, overweight 25-29.9 kg/m2, obese: ≥30 kg/m2], waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) using Cox proportional hazards models.Results: Among men, a BMI < 22.5 kg/m2 was associated with higher head and neck cancer risk [HR 1.62; 95% confidence interval (CI), 1.23-2.12)]; BMI was not associated with head and neck cancer among women. WC and WHR were associated with greater risk of head and neck cancer among women (WC per 5 cm: HR, 1.08; 95% CI, 1.02-1.15; WHR per 0.1 unit: HR, 1.64; 95% CI, 1.38-1.93). After stratification by smoking status, the association for WHR was present only among smokers (Pinteraction = 0.004). Among men, WC and WHR were associated with head and neck cancer only upon additional adjustment for BMI (WC per 5 cm: HR 1.16; 95% CI, 1.07-1.26; WHR per 0.1 unit: HR, 1.42; 95% CI, 1.21-1.65).Conclusions: Central adiposity, particularly among women, may have a stronger association with head and neck cancer risk than previously estimated.Impact: Strategies to reduce obesity may beneficially impact head and neck cancer incidence. Cancer Epidemiol Biomarkers Prev; 26(6); 895-904. ©2017 AACR.


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