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    Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

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    Authors
    Stepien, Magdalena
    Jenab, Mazda
    Freisling, Heinz
    Becker, Niels-Peter
    Czuban, Magdalena
    Tjønneland, Anne
    Olsen, Anja
    Overvad, Kim
    Boutron-Ruault, Marie-Christine
    Mancini, Francesca Romana
    Savoye, Isabelle
    Katzke, Verena
    Kühn, Tilman
    Boeing, Heiner
    Iqbal, Khalid
    Trichopoulou, Antonia
    Bamia, Christina
    Orfanos, Philippos
    Palli, Domenico
    Sieri, Sabina
    Tumino, Rosario
    Naccarati, Alessio
    Panico, Salvatore
    Bueno-de-Mesquita, H B As
    Peeters, Petra H
    Weiderpass, Elisabete
    Merino, Susana
    Jakszyn, Paula
    Sanchez, Maria-Jose
    Dorronsoro, Miren
    Huerta, José María
    Barricarte, Aurelio
    Boden, Stina
    van Guelpen, Behany
    Wareham, Nick
    Khaw, Kay-Tee
    Bradbury, Kathryn E
    Cross, Amanda J
    Schomburg, Lutz
    Hughes, David J
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    Type
    Article
    Language
    en
    
    Metadata
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    Title
    Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.
    Published in
    Carcinogenesis 2017; 38(7):699-707
    Publiekssamenvatting
    Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative stress is thought to be etiologically involved. As evidence from prospective epidemiologic studies is lacking, we conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to investigate the association between circulating levels of copper and zinc, and their calculated ratio, with risk of CRC development. Copper and zinc levels were measured by reflection X-ray fluorescence spectrometer in 966 cases and 966 matched controls. Multivariable adjusted odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional logistic regression and are presented for the fifth versus first quintile. Higher circulating concentration of copper was associated with a raised CRC risk (OR = 1.50; 95% CI: 1.06, 2.13; P-trend = 0.02) whereas an inverse association with cancer risk was observed for higher zinc levels (OR = 0.65; 95% CI: 0.43, 0.97; P-trend = 0.07). Consequently, the ratio of copper/zinc was positively associated with CRC (OR = 1.70; 95% CI: 1.20, 2.40; P-trend = 0.0005). In subgroup analyses by follow-up time, the associations remained statistically significant only in those diagnosed within 2 years of blood collection. In conclusion, these data suggest that copper or copper levels in relation to zinc (copper to zinc ratio) become imbalanced in the process of CRC development. Mechanistic studies into the underlying mechanisms of regulation and action are required to further examine a possible role for higher copper and copper/zinc ratio levels in CRC development and progression.
    DOI
    10.1093/carcin/bgx051
    PMID
    28575311
    URI
    http://hdl.handle.net/10029/621240
    ae974a485f413a2113503eed53cd6c53
    10.1093/carcin/bgx051
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