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dc.contributor.authorKuiken, Thijs
dc.contributor.authorBreitbart, Mya
dc.contributor.authorBeer, Martin
dc.contributor.authorGrund, Christian
dc.contributor.authorHöper, Dirk
dc.contributor.authorvan den Hoogen, Bernadette
dc.contributor.authorKerkhoffs, Jean-Louis H
dc.contributor.authorKroes, Aloys C M
dc.contributor.authorRosario, Karyna
dc.contributor.authorvan Run, Peter
dc.contributor.authorSchwarz, Matthias
dc.contributor.authorSvraka, Sanela
dc.contributor.authorTeifke, Jens
dc.contributor.authorKoopmans, Marion
dc.date.accessioned2018-02-01T11:44:07Z
dc.date.available2018-02-01T11:44:07Z
dc.date.issued2018-01-24
dc.identifier.citationZoonotic Infection with Pigeon Paramyxovirus Type 1 linked to Fatal Pneumonia. 2018 J. Infect. Dis.en
dc.identifier.issn1537-6613
dc.identifier.pmid29373675
dc.identifier.doi10.1093/infdis/jiy036
dc.identifier.urihttp://hdl.handle.net/10029/621278
dc.description.abstractThe characteristics and risk factors of pigeon paramyxovirus type 1 (PPMV-1) infection in humans are poorly known. We performed virological, pathological and epidemiological analyses of a Dutch case, and compared the results with those of a US case. Both infections occurred in transplant patients under immunosuppressive therapy and caused fatal respiratory failure. Both virus isolates clustered with avian paramyxovirus type 1 (APMV-1) genotype VIb/1, which has pigeons and doves as reservoir. Experimentally inoculated pigeons became infected and transmitted the virus to naïve pigeons. Likely route of transmission to both patients was direct or indirect contact with infected pigeons or doves. Given the large populations of feral pigeons with endemic PPMV-1 infection in cities, increasing urbanisation and a higher proportion of immunocompromised individuals, the risk of severe human PPMV-1 infections may increase. We recommend to test for APMV-1, including PPMV-1, in respiratory disease cases where common respiratory pathogens cannot be identified.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleZoonotic Infection with Pigeon Paramyxovirus Type 1 linked to Fatal Pneumonia.en
dc.typeArticleen
dc.identifier.journalJ Infect Dis 2018; advance online publication (ahead of print)en
html.description.abstractThe characteristics and risk factors of pigeon paramyxovirus type 1 (PPMV-1) infection in humans are poorly known. We performed virological, pathological and epidemiological analyses of a Dutch case, and compared the results with those of a US case. Both infections occurred in transplant patients under immunosuppressive therapy and caused fatal respiratory failure. Both virus isolates clustered with avian paramyxovirus type 1 (APMV-1) genotype VIb/1, which has pigeons and doves as reservoir. Experimentally inoculated pigeons became infected and transmitted the virus to naïve pigeons. Likely route of transmission to both patients was direct or indirect contact with infected pigeons or doves. Given the large populations of feral pigeons with endemic PPMV-1 infection in cities, increasing urbanisation and a higher proportion of immunocompromised individuals, the risk of severe human PPMV-1 infections may increase. We recommend to test for APMV-1, including PPMV-1, in respiratory disease cases where common respiratory pathogens cannot be identified.


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