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dc.contributor.authorZamora-Ros, Raul
dc.contributor.authorCastañeda, Jazmín
dc.contributor.authorRinaldi, Sabina
dc.contributor.authorCayssials, Valerie
dc.contributor.authorSlimani, Nadia
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorTsilidis, Konstantinos K
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorOvervad, Kim
dc.contributor.authorEriksen, Anne K
dc.contributor.authorTjønneland, Anne
dc.contributor.authorKühn, Tilman
dc.contributor.authorKatzke, Verena
dc.contributor.authorBoeing, Heiner
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLa Vecchia, Carlo
dc.contributor.authorKotanidou, Anastasia
dc.contributor.authorPalli, Domenico
dc.contributor.authorGrioni, Sara
dc.contributor.authorMattiello, Amalia
dc.contributor.authorTumino, Rosario
dc.contributor.authorSciannameo, Veronica
dc.contributor.authorLund, Eiliv
dc.contributor.authorMerino, Susana
dc.contributor.authorSalamanca-Fernández, Elena
dc.contributor.authorAmiano, Pilar
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorEricson, Ulrika
dc.contributor.authorAlmquist, Martin
dc.contributor.authorHennings, Joakim
dc.contributor.authorSandström, Maria
dc.contributor.authorBueno-de-Mesquita, H Bas
dc.contributor.authorPeeters, Petra H
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorSchmidt, Julie A
dc.contributor.authorCross, Amanda J
dc.contributor.authorRiboli, Elio
dc.contributor.authorScalbert, Augustin
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorAgudo, Antonio
dc.contributor.authorFranceschi, Silvia
dc.date.accessioned2018-02-07T07:29:04Z
dc.date.available2018-02-07T07:29:04Z
dc.date.issued2017
dc.identifier.citationConsumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. 2017, 147 (7):1366-1373 J. Nutr.en
dc.identifier.issn1541-6100
dc.identifier.pmid28592517
dc.identifier.doi10.3945/jn.117.247874
dc.identifier.urihttp://hdl.handle.net/10029/621325
dc.description.abstractBackground: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using country-specific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors.Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence.Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAnimals
dc.subject.meshCohort Studies
dc.subject.meshDiet
dc.subject.meshEurope
dc.subject.meshFemale
dc.subject.meshFishes
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshRisk Factors
dc.subject.meshThyroid Neoplasms
dc.titleConsumption of Fish Is Not Associated with Risk of Differentiated Thyroid Carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.en
dc.typeArticleen
dc.identifier.journalJ Nutr 2017; 47(7):1366-73en
html.description.abstractBackground: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk.Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Methods: EPIC is a cohort of >500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using country-specific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors.Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence.Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare.


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