Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Booth, Andy M
Brain, Joseph D
Sips, Adriënne J A M
Yokel, Robert A
MetadataShow full item record
TitleBiokinetics of Nanomaterials: the Role of Biopersistence.
Published inNanoImpact 2017; 6:69-80
PubliekssamenvattingNanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity of NMs. It is unclear which criteria to apply to characterize a NM as biopersistent. Detection and quantification of NMs, especially determination of their state, i.e., dissolution, aggregation, and agglomeration within biological matrices and other environments are still challenging tasks; moreover mechanisms of nanoparticle (NP) translocation and persistence remain critical gaps. This review summarizes the current understanding of NM biokinetics focusing on determinants of biopersistence. Thorough particle characterization in different exposure scenarios and biological matrices requires use of suitable analytical methods and is a prerequisite to understand biopersistence and for the development of appropriate dosimetry. Analytical tools that potentially can facilitate elucidation of key NM characteristics, such as ion beam microscopy (IBM) and time-of-flight secondary ion mass spectrometry (ToF-SIMS), are discussed in relation to their potential to advance the understanding of biopersistent NM kinetics. We conclude that a major requirement for future nanosafety research is the development and application of analytical tools to characterize NPs in different exposure scenarios and biological matrices.
- Nanomaterial translocation--the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs--a review.
- Authors: Kermanizadeh A, Balharry D, Wallin H, Loft S, Møller P
- Issue date: 2015
- Testing strategies to establish the safety of nanomaterials: conclusions of an ECETOC workshop.
- Authors: Warheit DB, Borm PJ, Hennes C, Lademann J
- Issue date: 2007 Jun
- Manufactured nanomaterials: categorization and approaches to hazard assessment.
- Authors: Gebel T, Foth H, Damm G, Freyberger A, Kramer PJ, Lilienblum W, Röhl C, Schupp T, Weiss C, Wollin KM, Hengstler JG
- Issue date: 2014 Dec
- Metabolism of nanomaterials in vivo: blood circulation and organ clearance.
- Authors: Wang B, He X, Zhang Z, Zhao Y, Feng W
- Issue date: 2013 Mar 19
- Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology.
- Authors: Oberdörster G
- Issue date: 2010 Jan