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    Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.

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    Authors
    van der Lee, Saskia
    Kemmeren, Jeanet M
    de Rond, Lia G H
    Öztürk, Kemal
    Westerhof, Anneke
    de Melker, Hester E
    Sanders, Elisabeth A M
    Berbers, Guy A M
    van der Maas, Nicoline A T
    Rümke, Hans C
    Buisman, Anne-Marie
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    Type
    Article
    Language
    en
    
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    Title
    Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.
    Published in
    Pediatr Infect Dis J 2017; 36(9):e223-9
    Publiekssamenvatting
    In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.
    DOI
    10.1097/INF.0000000000001620
    PMID
    28430750
    URI
    http://hdl.handle.net/10029/621343
    ae974a485f413a2113503eed53cd6c53
    10.1097/INF.0000000000001620
    Scopus Count
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