Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.
dc.contributor.author | van der Lee, Saskia | |
dc.contributor.author | Kemmeren, Jeanet M | |
dc.contributor.author | de Rond, Lia G H | |
dc.contributor.author | Öztürk, Kemal | |
dc.contributor.author | Westerhof, Anneke | |
dc.contributor.author | de Melker, Hester E | |
dc.contributor.author | Sanders, Elisabeth A M | |
dc.contributor.author | Berbers, Guy A M | |
dc.contributor.author | van der Maas, Nicoline A T | |
dc.contributor.author | Rümke, Hans C | |
dc.contributor.author | Buisman, Anne-Marie | |
dc.date.accessioned | 2018-02-07T08:02:58Z | |
dc.date.available | 2018-02-07T08:02:58Z | |
dc.date.issued | 2017-09 | |
dc.identifier.citation | Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. 2017, 36 (9):e223-e229 Pediatr. Infect. Dis. J. | en |
dc.identifier.issn | 1532-0987 | |
dc.identifier.pmid | 28430750 | |
dc.identifier.doi | 10.1097/INF.0000000000001620 | |
dc.identifier.uri | http://hdl.handle.net/10029/621343 | |
dc.description.abstract | In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination. | |
dc.language.iso | en | en |
dc.rights | info:eu-repo/semantics/closedAccess | en |
dc.subject.mesh | Antibodies, Bacterial | |
dc.subject.mesh | Antigens, Bacterial | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Cells, Cultured | |
dc.subject.mesh | Child, Preschool | |
dc.subject.mesh | Cytokines | |
dc.subject.mesh | Diphtheria-Tetanus-acellular Pertussis Vaccines | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunization, Secondary | |
dc.subject.mesh | Immunoglobulin G | |
dc.subject.mesh | Inflammation | |
dc.subject.mesh | Leukocytes, Mononuclear | |
dc.subject.mesh | Male | |
dc.subject.mesh | Netherlands | |
dc.title | Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. | en |
dc.type | Article | en |
dc.identifier.journal | Pediatr Infect Dis J 2017; 36(9):e223-9 | en |
html.description.abstract | In the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination. |