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dc.contributor.authorvan der Lee, Saskia
dc.contributor.authorKemmeren, Jeanet M
dc.contributor.authorde Rond, Lia G H
dc.contributor.authorÖztürk, Kemal
dc.contributor.authorWesterhof, Anneke
dc.contributor.authorde Melker, Hester E
dc.contributor.authorSanders, Elisabeth A M
dc.contributor.authorBerbers, Guy A M
dc.contributor.authorvan der Maas, Nicoline A T
dc.contributor.authorRümke, Hans C
dc.contributor.authorBuisman, Anne-Marie
dc.date.accessioned2018-02-07T08:02:58Z
dc.date.available2018-02-07T08:02:58Z
dc.date.issued2017-09
dc.identifier.citationElevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination. 2017, 36 (9):e223-e229 Pediatr. Infect. Dis. J.en
dc.identifier.issn1532-0987
dc.identifier.pmid28430750
dc.identifier.doi10.1097/INF.0000000000001620
dc.identifier.urihttp://hdl.handle.net/10029/621343
dc.description.abstractIn the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.subject.meshAntibodies, Bacterial
dc.subject.meshAntigens, Bacterial
dc.subject.meshCase-Control Studies
dc.subject.meshCells, Cultured
dc.subject.meshChild, Preschool
dc.subject.meshCytokines
dc.subject.meshDiphtheria-Tetanus-acellular Pertussis Vaccines
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunization, Secondary
dc.subject.meshImmunoglobulin G
dc.subject.meshInflammation
dc.subject.meshLeukocytes, Mononuclear
dc.subject.meshMale
dc.subject.meshNetherlands
dc.titleElevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination.en
dc.typeArticleen
dc.identifier.journalPediatr Infect Dis J 2017; 36(9):e223-9en
html.description.abstractIn the Netherlands, acellular pertussis vaccines replaced the more reactogenic whole-cell pertussis vaccines. This replacement in the primary immunization schedule of infants coincided with a significant increase in pronounced local adverse events (AEs) in 4 years old children shortly after the administration of a fifth diphtheria, tetanus, acellular pertussis and inactivated polio (DTaP-IPV) vaccine. The objective of this study was to investigate possible differences in vaccine antigen-specific immune responses between children with and without a pronounced local AE after the fifth DTaP-IPV vaccination.


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