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    Pharmacokinetics of favipiravir during continuous venovenous haemofiltration in a critically ill patient with influenza.

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    Authors
    Favié, Laurent Ma
    Murk, Jean-Luc
    Meijer, Adam
    Nijstad, A Laura
    van Maarseveen, Erik M
    Sikma, Maaike A
    Type
    Article
    Language
    en
    
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    Title
    Pharmacokinetics of favipiravir during continuous venovenous haemofiltration in a critically ill patient with influenza.
    Published in
    Antivir Ther 2018; 23(5):457-61
    Publiekssamenvatting
    Favipiravir is a novel antiviral drug approved for influenza treatment in Japan. Little is known about favipiravir pharmacokinetics in critically ill patients. Here, we report a patient with influenza treated with favipiravir and undergoing continuous venovenous hemofiltration (CVVH) on the Intensive Care Unit of a tertiary hospital in the Netherlands. Pharmacokinetic analyses showed increased clearance and decreased plasma levels compared to healthy volunteers. CVVH has no clinically relevant contribution to total clearance. Despite susceptibility to favipiravir, the influenza virus was not cleared. A multi-disciplinary approach is needed to ensure optimal favipiravir treatment in critically ill patients.
    DOI
    10.3851/IMP3210
    PMID
    29185991
    URI
    http://hdl.handle.net/10029/621381
    ae974a485f413a2113503eed53cd6c53
    10.3851/IMP3210
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