Show simple item record

dc.contributor.authorShugay, Mikhail
dc.contributor.authorBagaev, Dmitriy V
dc.contributor.authorZvyagin, Ivan V
dc.contributor.authorVroomans, Renske M
dc.contributor.authorCrawford, Jeremy Chase
dc.contributor.authorDolton, Garry
dc.contributor.authorKomech, Ekaterina A
dc.contributor.authorSycheva, Anastasiya L
dc.contributor.authorKoneva, Anna E
dc.contributor.authorEgorov, Evgeniy S
dc.contributor.authorEliseev, Alexey V
dc.contributor.authorVan Dyk, Ewald
dc.contributor.authorDash, Pradyot
dc.contributor.authorAttaf, Meriem
dc.contributor.authorRius, Cristina
dc.contributor.authorLadell, Kristin
dc.contributor.authorMcLaren, James E
dc.contributor.authorMatthews, Katherine K
dc.contributor.authorClemens, E Bridie
dc.contributor.authorDouek, Daniel C
dc.contributor.authorLuciani, Fabio
dc.contributor.authorvan Baarle, Debbie
dc.contributor.authorKedzierska, Katherine
dc.contributor.authorKesmir, Can
dc.contributor.authorThomas, Paul G
dc.contributor.authorPrice, David A
dc.contributor.authorSewell, Andrew K
dc.contributor.authorChudakov, Dmitriy M
dc.date.accessioned2018-02-09T08:26:58Z
dc.date.available2018-02-09T08:26:58Z
dc.date.issued2018-01-04
dc.identifier.citationVDJdb: a curated database of T-cell receptor sequences with known antigen specificity. 2018, 46 (D1):D419-D427 Nucleic Acids Res.en
dc.identifier.issn1362-4962
dc.identifier.pmid28977646
dc.identifier.doi10.1093/nar/gkx760
dc.identifier.urihttp://hdl.handle.net/10029/621387
dc.description.abstractThe ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine. Recent developments in high-throughput sequencing methods (immune repertoire sequencing technology, or RepSeq) and single-cell RNA sequencing technology have allowed us to obtain huge numbers of TCR sequences from donor samples and link them to T-cell phenotypes. However, our ability to annotate these TCR sequences still lags behind, owing to the enormous diversity of the TCR repertoire and the scarcity of available data on T-cell specificities. In this paper, we present VDJdb, a database that stores and aggregates the results of published T-cell specificity assays and provides a universal platform that couples antigen specificities with TCR sequences. We demonstrate that VDJdb is a versatile instrument for the annotation of TCR repertoire data, enabling a concatenated view of antigen-specific TCR sequence motifs. VDJdb can be accessed at https://vdjdb.cdr3.net and https://github.com/antigenomics/vdjdb-db.
dc.language.isoenen
dc.rightsArchived with thanks to Nucleic acids researchen
dc.titleVDJdb: a curated database of T-cell receptor sequences with known antigen specificity.en
dc.typeArticleen
dc.identifier.journalNucleic Acids Res 2018; 46(D1):D419-27en
html.description.abstractThe ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine. Recent developments in high-throughput sequencing methods (immune repertoire sequencing technology, or RepSeq) and single-cell RNA sequencing technology have allowed us to obtain huge numbers of TCR sequences from donor samples and link them to T-cell phenotypes. However, our ability to annotate these TCR sequences still lags behind, owing to the enormous diversity of the TCR repertoire and the scarcity of available data on T-cell specificities. In this paper, we present VDJdb, a database that stores and aggregates the results of published T-cell specificity assays and provides a universal platform that couples antigen specificities with TCR sequences. We demonstrate that VDJdb is a versatile instrument for the annotation of TCR repertoire data, enabling a concatenated view of antigen-specific TCR sequence motifs. VDJdb can be accessed at https://vdjdb.cdr3.net and https://github.com/antigenomics/vdjdb-db.


This item appears in the following Collection(s)

Show simple item record