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    Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.

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    Authors
    Butt, Julia
    Jenab, Mazda
    Willhauck-Fleckenstein, Martina
    Michel, Angelika
    Pawlita, Michael
    Kyrø, Cecilie
    Tjønneland, Anne
    Boutron-Ruault, Marie-Christine
    Carbonnel, Franck
    Severi, Gianluca
    Kaaks, Rudolf
    Kühn, Tilman
    Boeing, Heiner
    Trichopoulou, Antonia
    la Vecchia, Carlo
    Karakatsani, Anna
    Panico, Salvatore
    Tumino, Rosario
    Agnoli, Claudia
    Palli, Domenico
    Sacerdote, Carlotta
    Bueno-de-Mesquita, Bas
    Weiderpass, Elisabete
    Sánchez, Maria-José
    Bonet Bonet, Catalina
    Huerta, JoséMaría
    Ardanaz, Eva
    Bradbury, Kathryn
    Gunter, Marc
    Murphy, Neil
    Freisling, Heinz
    Riboli, Elio
    Tsilidis, Kostas
    Aune, Dagfinn
    Waterboer, Tim
    Hughes, David
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    Type
    Article
    Language
    en
    
    Metadata
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    Title
    Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.
    Published in
    Int J cancer 2018; advance online publication (ahead of print)
    Publiekssamenvatting
    The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC risk in a case-control study nested within a prospective cohort. Pre-diagnostic serum samples from 485 first incident CRC cases (mean time between blood draw and diagnosis 3.4 years) and 485 matched controls in the European Prospective Investigation into Nutrition and Cancer (EPIC) study were analyzed for antibody responses to eleven SGG proteins using multiplex serology. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable conditional logistic regression models. Antibody positivity for any of the eleven SGG proteins was significantly associated with CRC risk with 56% positive controls compared to 63% positive cases (OR: 1.36, 95% CI: 1.04-1.77). Positivity for two or more proteins of a previously identified SGG 6-marker panel with greater CRC-specificity was also observed among 9% of controls compared to 17% of CRC cases, corresponding to a significantly increased CRC risk (OR: 2.17, 95% CI: 1.44-3.27). In this prospective nested case-control study we observed a positive association between antibody responses to SGG and CRC development in serum samples taken pre-diagnostically. Further work is required to establish the possibly etiological significance of these observations and whether SGG serology may be applicable for CRC risk stratification. This article is protected by copyright. All rights reserved.
    DOI
    10.1002/ijc.31283
    PMID
    29377173
    URI
    http://hdl.handle.net/10029/621391
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.31283
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