Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
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Authors
Klein, Alison PWolpin, Brian M
Risch, Harvey A
Stolzenberg-Solomon, Rachael Z
Mocci, Evelina
Zhang, Mingfeng
Canzian, Federico
Childs, Erica J
Hoskins, Jason W
Jermusyk, Ashley
Zhong, Jun
Sund, Malin
Talar-Wojnarowska, Renata
Tavano, Francesca
Thornquist, Mark D
Tobias, Geoffrey S
Van Den Eeden, Stephen K
Vashist, Yogesh
Visvanathan, Kala
Vodicka, Pavel
Wactawski-Wende, Jean
Chen, Fei
Wang, Zhaoming
Wentzensen, Nicolas
White, Emily
Yu, Herbert
Yu, Kai
Zeleniuch-Jacquotte, Anne
Zheng, Wei
Kraft, Peter
Li, Donghui
Chanock, Stephen
Albanes, Demetrius
Obazee, Ofure
Petersen, Gloria M
Amundadottir, Laufey T
Andreotti, Gabriella
Arslan, Alan A
Babic, Ana
Bamlet, William R
Beane-Freeman, Laura
Berndt, Sonja I
Blackford, Amanda
Borges, Michael
Borgida, Ayelet
Bracci, Paige M
Brais, Lauren
Brennan, Paul
Brenner, Hermann
Bueno-de-Mesquita, Bas
Buring, Julie
Campa, Daniele
Capurso, Gabriele
Cavestro, Giulia Martina
Chaffee, Kari G
Chung, Charles C
Cleary, Sean
Cotterchio, Michelle
Dijk, Frederike
Duell, Eric J
Foretova, Lenka
Fuchs, Charles
Funel, Niccola
Gallinger, Steven
M Gaziano, J Michael
Gazouli, Maria
Giles, Graham G
Giovannucci, Edward
Goggins, Michael
Goodman, Gary E
Goodman, Phyllis J
Hackert, Thilo
Haiman, Christopher
Hartge, Patricia
Hasan, Manal
Hegyi, Peter
Helzlsouer, Kathy J
Herman, Joseph
Holcatova, Ivana
Holly, Elizabeth A
Hoover, Robert
Hung, Rayjean J
Jacobs, Eric J
Jamroziak, Krzysztof
Janout, Vladimir
Kaaks, Rudolf
Khaw, Kay-Tee
Klein, Eric A
Kogevinas, Manolis
Kooperberg, Charles
Kulke, Matthew H
Kupcinskas, Juozas
Kurtz, Robert J
Laheru, Daniel
Landi, Stefano
Lawlor, Rita T
Lee, I-Min
LeMarchand, Loic
Lu, Lingeng
Malats, Núria
Mambrini, Andrea
Mannisto, Satu
Milne, Roger L
Mohelníková-Duchoňová, Beatrice
Neale, Rachel E
Neoptolemos, John P
Oberg, Ann L
Olson, Sara H
Orlow, Irene
Pasquali, Claudio
Patel, Alpa V
Peters, Ulrike
Pezzilli, Raffaele
Porta, Miquel
Real, Francisco X
Rothman, Nathaniel
Scelo, Ghislaine
Sesso, Howard D
Severi, Gianluca
Shu, Xiao-Ou
Silverman, Debra
Smith, Jill P
Soucek, Pavel
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ArticleLanguage
en
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Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.Published in
Nat Commun 2018; 9(1):556Publiekssamenvatting
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.PMID
29422604ae974a485f413a2113503eed53cd6c53
10.1038/s41467-018-02942-5
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