Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

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Authors
Klein, Alison P
Wolpin, Brian M
Risch, Harvey A
Stolzenberg-Solomon, Rachael Z
Mocci, Evelina
Zhang, Mingfeng
Canzian, Federico
Childs, Erica J
Hoskins, Jason W
Jermusyk, AshleyZhong, JunSund, MalinTalar-Wojnarowska, RenataTavano, FrancescaThornquist, Mark DTobias, Geoffrey SVan Den Eeden, Stephen KVashist, YogeshVisvanathan, KalaVodicka, PavelWactawski-Wende, JeanChen, FeiWang, ZhaomingWentzensen, NicolasWhite, EmilyYu, HerbertYu, KaiZeleniuch-Jacquotte, AnneZheng, WeiKraft, PeterLi, DonghuiChanock, StephenAlbanes, DemetriusObazee, OfurePetersen, Gloria MAmundadottir, Laufey TAndreotti, GabriellaArslan, Alan ABabic, AnaBamlet, William RBeane-Freeman, LauraBerndt, Sonja IBlackford, AmandaBorges, MichaelBorgida, AyeletBracci, Paige MBrais, LaurenBrennan, PaulBrenner, HermannBueno-de-Mesquita, BasBuring, JulieCampa, DanieleCapurso, GabrieleCavestro, Giulia MartinaChaffee, Kari GChung, Charles CCleary, SeanCotterchio, MichelleDijk, FrederikeDuell, Eric JForetova, LenkaFuchs, CharlesFunel, NiccolaGallinger, StevenM Gaziano, J MichaelGazouli, MariaGiles, Graham GGiovannucci, EdwardGoggins, MichaelGoodman, Gary EGoodman, Phyllis JHackert, ThiloHaiman, ChristopherHartge, PatriciaHasan, ManalHegyi, PeterHelzlsouer, Kathy JHerman, JosephHolcatova, IvanaHolly, Elizabeth AHoover, RobertHung, Rayjean JJacobs, Eric JJamroziak, KrzysztofJanout, VladimirKaaks, RudolfKhaw, Kay-TeeKlein, Eric AKogevinas, ManolisKooperberg, CharlesKulke, Matthew HKupcinskas, JuozasKurtz, Robert JLaheru, DanielLandi, StefanoLawlor, Rita TLee, I-MinLeMarchand, LoicLu, LingengMalats, NúriaMambrini, AndreaMannisto, SatuMilne, Roger LMohelníková-Duchoňová, BeatriceNeale, Rachel ENeoptolemos, John POberg, Ann LOlson, Sara HOrlow, IrenePasquali, ClaudioPatel, Alpa VPeters, UlrikePezzilli, RaffaelePorta, MiquelReal, Francisco XRothman, NathanielScelo, GhislaineSesso, Howard DSeveri, GianlucaShu, Xiao-OuSilverman, DebraSmith, Jill PSoucek, Pavel
Type
Article
Language
en

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Title
Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
Published in
Nat Commun 2018; 9(1):556
Publiekssamenvatting
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
DOI
10.1038/s41467-018-02942-5
PMID
29422604
URI
http://hdl.handle.net/10029/621401
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