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    Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

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    Authors
    Klein, Alison P
    Wolpin, Brian M
    Risch, Harvey A
    Stolzenberg-Solomon, Rachael Z
    Mocci, Evelina
    Zhang, Mingfeng
    Canzian, Federico
    Childs, Erica J
    Hoskins, Jason W
    Jermusyk, Ashley
    Zhong, Jun
    Sund, Malin
    Talar-Wojnarowska, Renata
    Tavano, Francesca
    Thornquist, Mark D
    Tobias, Geoffrey S
    Van Den Eeden, Stephen K
    Vashist, Yogesh
    Visvanathan, Kala
    Vodicka, Pavel
    Wactawski-Wende, Jean
    Chen, Fei
    Wang, Zhaoming
    Wentzensen, Nicolas
    White, Emily
    Yu, Herbert
    Yu, Kai
    Zeleniuch-Jacquotte, Anne
    Zheng, Wei
    Kraft, Peter
    Li, Donghui
    Chanock, Stephen
    Albanes, Demetrius
    Obazee, Ofure
    Petersen, Gloria M
    Amundadottir, Laufey T
    Andreotti, Gabriella
    Arslan, Alan A
    Babic, Ana
    Bamlet, William R
    Beane-Freeman, Laura
    Berndt, Sonja I
    Blackford, Amanda
    Borges, Michael
    Borgida, Ayelet
    Bracci, Paige M
    Brais, Lauren
    Brennan, Paul
    Brenner, Hermann
    Bueno-de-Mesquita, Bas
    Buring, Julie
    Campa, Daniele
    Capurso, Gabriele
    Cavestro, Giulia Martina
    Chaffee, Kari G
    Chung, Charles C
    Cleary, Sean
    Cotterchio, Michelle
    Dijk, Frederike
    Duell, Eric J
    Foretova, Lenka
    Fuchs, Charles
    Funel, Niccola
    Gallinger, Steven
    M Gaziano, J Michael
    Gazouli, Maria
    Giles, Graham G
    Giovannucci, Edward
    Goggins, Michael
    Goodman, Gary E
    Goodman, Phyllis J
    Hackert, Thilo
    Haiman, Christopher
    Hartge, Patricia
    Hasan, Manal
    Hegyi, Peter
    Helzlsouer, Kathy J
    Herman, Joseph
    Holcatova, Ivana
    Holly, Elizabeth A
    Hoover, Robert
    Hung, Rayjean J
    Jacobs, Eric J
    Jamroziak, Krzysztof
    Janout, Vladimir
    Kaaks, Rudolf
    Khaw, Kay-Tee
    Klein, Eric A
    Kogevinas, Manolis
    Kooperberg, Charles
    Kulke, Matthew H
    Kupcinskas, Juozas
    Kurtz, Robert J
    Laheru, Daniel
    Landi, Stefano
    Lawlor, Rita T
    Lee, I-Min
    LeMarchand, Loic
    Lu, Lingeng
    Malats, Núria
    Mambrini, Andrea
    Mannisto, Satu
    Milne, Roger L
    Mohelníková-Duchoňová, Beatrice
    Neale, Rachel E
    Neoptolemos, John P
    Oberg, Ann L
    Olson, Sara H
    Orlow, Irene
    Pasquali, Claudio
    Patel, Alpa V
    Peters, Ulrike
    Pezzilli, Raffaele
    Porta, Miquel
    Real, Francisco X
    Rothman, Nathaniel
    Scelo, Ghislaine
    Sesso, Howard D
    Severi, Gianluca
    Shu, Xiao-Ou
    Silverman, Debra
    Smith, Jill P
    Soucek, Pavel
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    Type
    Article
    Language
    en
    
    Metadata
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    Title
    Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.
    Published in
    Nat Commun 2018; 9(1):556
    Publiekssamenvatting
    In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene.
    DOI
    10.1038/s41467-018-02942-5
    PMID
    29422604
    URI
    http://hdl.handle.net/10029/621401
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41467-018-02942-5
    Scopus Count
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