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dc.contributor.authorFitzner, Julia
dc.contributor.authorQasmieh, Saba
dc.contributor.authorMounts, Anthony Wayne
dc.contributor.authorAlexander, Burmaa
dc.contributor.authorBesselaar, Terry
dc.contributor.authorBriand, Sylvie
dc.contributor.authorBrown, Caroline
dc.contributor.authorClark, Seth
dc.contributor.authorDueger, Erica
dc.contributor.authorGross, Diane
dc.contributor.authorHauge, Siri
dc.contributor.authorHirve, Siddhivinayak
dc.contributor.authorJorgensen, Pernille
dc.contributor.authorKatz, Mark A
dc.contributor.authorMafi, Ali
dc.contributor.authorMalik, Mamunur
dc.contributor.authorMcCarron, Margaret
dc.contributor.authorMeerhoff, Tamara
dc.contributor.authorMori, Yuichiro
dc.contributor.authorMott, Joshua
dc.contributor.authorOlivera, Maria Teresa da Costa
dc.contributor.authorOrtiz, Justin R
dc.contributor.authorPalekar, Rakhee
dc.contributor.authorRebelo-de-Andrade, Helena
dc.contributor.authorSoetens, Loes
dc.contributor.authorYahaya, Ali Ahmed
dc.contributor.authorZhang, Wenqing
dc.contributor.authorVandemaele, Katelijn
dc.date.accessioned2018-02-12T13:33:58Z
dc.date.available2018-02-12T13:33:58Z
dc.date.issued2018-02-01
dc.identifier.citationRevision of clinical case definitions: influenza-like illness and severe acute respiratory infection. 2018, 96 (2):122-128 Bull. World Health Organ.en
dc.identifier.issn1564-0604
dc.identifier.pmid29403115
dc.identifier.doi10.2471/BLT.17.194514
dc.identifier.urihttp://hdl.handle.net/10029/621413
dc.description.abstractThe formulation of accurate clinical case definitions is an integral part of an effective process of public health surveillance. Although such definitions should, ideally, be based on a standardized and fixed collection of defining criteria, they often require revision to reflect new knowledge of the condition involved and improvements in diagnostic testing. Optimal case definitions also need to have a balance of sensitivity and specificity that reflects their intended use. After the 2009-2010 H1N1 influenza pandemic, the World Health Organization (WHO) initiated a technical consultation on global influenza surveillance. This prompted improvements in the sensitivity and specificity of the case definition for influenza - i.e. a respiratory disease that lacks uniquely defining symptomology. The revision process not only modified the definition of influenza-like illness, to include a simplified list of the criteria shown to be most predictive of influenza infection, but also clarified the language used for the definition, to enhance interpretability. To capture severe cases of influenza that required hospitalization, a new case definition was also developed for severe acute respiratory infection in all age groups. The new definitions have been found to capture more cases without compromising specificity. Despite the challenge still posed in the clinical separation of influenza from other respiratory infections, the global use of the new WHO case definitions should help determine global trends in the characteristics and transmission of influenza viruses and the associated disease burden.
dc.language.isoenen
dc.rightsArchived with thanks to Bulletin of the World Health Organizationen
dc.titleRevision of clinical case definitions: influenza-like illness and severe acute respiratory infection.en
dc.typeArticleen
dc.identifier.journalBull World Health Organ 2018; 96(2):122-8en
html.description.abstractThe formulation of accurate clinical case definitions is an integral part of an effective process of public health surveillance. Although such definitions should, ideally, be based on a standardized and fixed collection of defining criteria, they often require revision to reflect new knowledge of the condition involved and improvements in diagnostic testing. Optimal case definitions also need to have a balance of sensitivity and specificity that reflects their intended use. After the 2009-2010 H1N1 influenza pandemic, the World Health Organization (WHO) initiated a technical consultation on global influenza surveillance. This prompted improvements in the sensitivity and specificity of the case definition for influenza - i.e. a respiratory disease that lacks uniquely defining symptomology. The revision process not only modified the definition of influenza-like illness, to include a simplified list of the criteria shown to be most predictive of influenza infection, but also clarified the language used for the definition, to enhance interpretability. To capture severe cases of influenza that required hospitalization, a new case definition was also developed for severe acute respiratory infection in all age groups. The new definitions have been found to capture more cases without compromising specificity. Despite the challenge still posed in the clinical separation of influenza from other respiratory infections, the global use of the new WHO case definitions should help determine global trends in the characteristics and transmission of influenza viruses and the associated disease burden.


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