• Login
    View Item 
    •   Home
    • Articles and other publications by RIVM employees
    • Miscellaneous
    • View Item
    •   Home
    • Articles and other publications by RIVM employees
    • Miscellaneous
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    RIVM Publications RepositoryCommunitiesTitleAuthorsIssue DateSubmit Date

    My Account

    LoginRegister

    Statistics

    Display statistics

    Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Average rating
     
       votes
    Cast your vote
    You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
    Star rating
     
    Your vote was cast
    Thank you for your feedback
    Authors
    Fritsche, Ellen
    Grandjean, Philippe
    Crofton, Kevin M
    Aschner, Michael
    Goldberg, Alan
    Heinonen, Tuula
    Hessel, Ellen V S
    Hogberg, Helena
    Bennekou, Susanne Hougaard
    Lein, Pamela J
    Leist, Marcel
    Mundy, William R
    Paparella, Martin
    Piersma, Aldert H
    Sachana, Magdalini
    Schmuck, Gabriele
    Solecki, Roland
    Terron, Andrea
    Monnet-Tschudi, Florianne
    Wilks, Martin F
    Witters, Hilda
    Zurich, Marie-Gabrielle
    Bal-Price, Anna
    Show allShow less
    Type
    Article
    Language
    en
    
    Metadata
    Show full item record
    Title
    Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.
    Published in
    Toxicol Appl Pharmacol 2018; advance online publication (ahead of print)
    Publiekssamenvatting
    This consensus statement voices the agreement of scientific stakeholders from regulatory agencies, academia and industry that a new framework needs adopting for assessment of chemicals with the potential to disrupt brain development. An increased prevalence of neurodevelopmental disorders in children has been observed that cannot solely be explained by genetics and recently pre- and postnatal exposure to environmental chemicals has been suspected as a causal factor. There is only very limited information on neurodevelopmental toxicity, leaving thousands of chemicals, that are present in the environment, with high uncertainty concerning their developmental neurotoxicity (DNT) potential. Closing this data gap with the current test guideline approach is not feasible, because the in vivo bioassays are far too resource-intensive concerning time, money and number of animals. A variety of in vitro methods are now available, that have the potential to close this data gap by permitting mode-of-action-based DNT testing employing human stem cells-derived neuronal/glial models. In vitro DNT data together with in silico approaches will in the future allow development of predictive models for DNT effects. The ultimate application goals of these new approach methods for DNT testing are their usage for different regulatory purposes.
    DOI
    10.1016/j.taap.2018.02.004
    PMID
    29447839
    URI
    http://hdl.handle.net/10029/621427
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.taap.2018.02.004
    Scopus Count
    Collections
    Miscellaneous

    entitlement

    Related articles

    • Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods.
    • Authors: Bal-Price A, Pistollato F, Sachana M, Bopp SK, Munn S, Worth A
    • Issue date: 2018 Sep 1
    • Towards a regulatory use of alternative developmental neurotoxicity testing (DNT).
    • Authors: Terron A, Bennekou SH
    • Issue date: 2018 Sep 1
    • A better approach to in vivo developmental neurotoxicity assessment: Alignment of rodent testing with effects seen in children after neurotoxic exposures.
    • Authors: Vorhees CV, Sprowles JN, Regan SL, Williams MT
    • Issue date: 2018 Sep 1
    • An industry perspective: A streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity.
    • Authors: Li J, Settivari R, LeBaron MJ, Marty MS
    • Issue date: 2019 Jul
    • International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing.
    • Authors: Sachana M, Bal-Price A, Crofton KM, Bennekou SH, Shafer TJ, Behl M, Terron A
    • Issue date: 2019 Jan 1

    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.