Editorial: dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides.
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TitleEditorial: dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides.
Published inPart Fibre Toxicol 2018; 15(1):7
PubliekssamenvattingEpidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of particles to systemic circulation, activation of airway sensory nerves resulting in autonomic imbalance and particle-induced pulmonary inflammation and acute phase response.The acute phase response is the systemic response to acute and chronic inflammatory states caused by for example bacterial infection, virus infection, trauma and infarction. It is characterized by differential expression of ca. 50 different acute phase proteins including C-reactive protein and Serum amyloid A, which are the most differentially up-regulated acute phase response proteins. Blood levels of these two acute phase proteins are closely associated with risk of cardiovascular disease in epidemiological studies and SAA has been causally related to the formation of plaques in the aorta in animal studies.In a recent paper in Particle and Fibre Toxicology, Christian Monsé et al. provide evidence that inhalation of ZnO nanoparticles induces dose-dependent acute phase response in humans at dose levels well below the current mass-based occupational exposure limits in a number of countries including Germany, The Netherlands, UK, Sweden, Denmark and the US.Given the evidence suggesting a causal relationship between increased levels of serum amyloid A and atherosclerosis, the current results call for a re-evaluation of occupational exposure limits for a number of particle exposures including ZnO taking induction of acute phase response into account. Furthermore, it underscores cardiovascular disease as an occupational disease.
- Concentration-dependent systemic response after inhalation of nano-sized zinc oxide particles in human volunteers.
- Authors: Monsé C, Hagemeyer O, Raulf M, Jettkant B, van Kampen V, Kendzia B, Gering V, Kappert G, Weiss T, Ulrich N, Marek EM, Bünger J, Brüning T, Merget R
- Issue date: 2018 Feb 12
- Acute phase response and inflammation following pulmonary exposure to low doses of zinc oxide nanoparticles in mice.
- Authors: Hadrup N, Rahmani F, Jacobsen NR, Saber AT, Jackson P, Bengtson S, Williams A, Wallin H, Halappanavar S, Vogel U
- Issue date: 2019 Nov
- Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
- Authors: Vogel U, Saber AT, Jacobsen NR, Danielsen PH, Hougaard KS, Hadrup N
- Issue date: 2024 Feb
- Inhalation exposure during spray application and subsequent sanding of a wood sealant containing zinc oxide nanoparticles.
- Authors: Cooper MR, West GH, Burrelli LG, Dresser D, Griffin KN, Segrave AM, Perrenoud J, Lippy BE
- Issue date: 2017 Jul
- Occupational exposure levels of bioaerosol components are associated with serum levels of the acute phase protein Serum Amyloid A in greenhouse workers.
- Authors: Madsen AM, Thilsing T, Bælum J, Garde AH, Vogel U
- Issue date: 2016 Jan 20