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    Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.

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    Authors
    Harvala, Heli
    Broberg, Eeva
    Benschop, Kimberley
    Berginc, Natasa
    Ladhani, Shamez
    Susi, Petri
    Christiansen, Claus
    McKenna, James
    Allen, David
    Makiello, Phoebe
    McAllister, Georgina
    Carmen, Mirabelli
    Zakikhany, Katherina
    Dyrdak, Robert
    Nielsen, Xiaohui
    Madsen, Tina
    Paul, Joel
    Moore, Catherine
    von Eije, Karin
    Piralla, Antonio
    Carlier, Mieke
    Vanoverschelde, Laura
    Poelman, Randy
    Anton, Andrés
    López-Labrador, F Xavier
    Pellegrinelli, Laura
    Keeren, Kathrin
    Maier, Melanie
    Cassidy, Hayley
    Derdas, Stavros
    Savolainen-Kopra, Carita
    Diedrich, Sabine
    Nordbø, Svein
    Buesa, Javier
    Bailly, Jean-Luc
    Baldanti, Fausto
    MacAdam, Andrew
    Mirand, Audrey
    Dudman, Susanne
    Schuffenecker, Isabelle
    Kadambari, Seilesh
    Neyts, Johan
    Griffiths, Michael J
    Richter, Jan
    Margaretto, Cristina
    Govind, Sheila
    Morley, Ursula
    Adams, Ortwin
    Krokstad, Sidsel
    Dean, Jonathan
    Pons-Salort, Margarita
    Prochazka, Birgit
    Cabrerizo, Maria
    Majumdar, Manasi
    Nebbia, Gaia
    Wiewel, Maryse
    Cottrell, Simon
    Coyle, Peter
    Martin, Javier
    Moore, Catrin
    Midgley, Sofie
    Horby, Peter
    Wolthers, Katja
    Simmonds, Peter
    Niesters, Hubert
    Fischer, Thea K
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    Type
    Article
    Language
    en
    
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    Title
    Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.
    Published in
    J Clin Virol 2018; 101:11-7
    Publiekssamenvatting
    Enteroviruses (EV) can cause severe neurological and respiratory infections, and occasionally lead to devastating outbreaks as previously demonstrated with EV-A71 and EV-D68 in Europe. However, these infections are still often underdiagnosed and EV typing data is not currently collected at European level. In order to improve EV diagnostics, collate data on severe EV infections and monitor the circulation of EV types, we have established European non-polio enterovirus network (ENPEN). First task of this cross-border network has been to ensure prompt and adequate diagnosis of these infections in Europe, and hence we present recommendations for non-polio EV detection and typing based on the consensus view of this multidisciplinary team including experts from over 20 European countries. We recommend that respiratory and stool samples in addition to cerebrospinal fluid (CSF) and blood samples are submitted for EV testing from patients with suspected neurological infections. This is vital since viruses like EV-D68 are rarely detectable in CSF or stool samples. Furthermore, reverse transcriptase PCR (RT-PCR) targeting the 5'noncoding regions (5'NCR) should be used for diagnosis of EVs due to their sensitivity, specificity and short turnaround time. Sequencing of the VP1 capsid protein gene is recommended for EV typing; EV typing cannot be based on the 5'NCR sequences due to frequent recombination events and should not rely on virus isolation. Effective and standardized laboratory diagnostics and characterisation of circulating virus strains are the first step towards effective and continuous surveillance activities, which in turn will be used to provide better estimation on EV disease burden.
    DOI
    10.1016/j.jcv.2018.01.008
    PMID
    29414181
    URI
    http://hdl.handle.net/10029/621442
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jcv.2018.01.008
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