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    Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study.

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    Authors
    Lassale, Camille
    Curtis, Alyscia
    Abete, Itziar
    van der Schouw, Yvonne T
    Verschuren, W M Monique
    Lu, Yunxia
    Bueno-de-Mesquita, H B As
    Type
    Article
    Language
    en
    
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    Title
    Elements of the complete blood count associated with cardiovascular disease incidence: Findings from the EPIC-NL cohort study.
    Published in
    Sci Rep 2018; 8(1):3290
    Publiekssamenvatting
    All blood cells (white blood cells [WBC], red blood cells [RBC] and platelets) can play a role in atherosclerosis. Complete blood count (CBC) is widely available in clinical practice but utility as potential risk factors for cardiovascular disease (CVD) is uncertain. Our aim was to assess the associations of pre-diagnostic CBC with incidence of CVD in 14,362 adults free of CVD and aged 47.8 (±11.7) years at baseline, followed-up for 11.4 years (992 incident cases). Cox proportional hazards regressions were used to estimate HRs and 95%CI. Comparing the top (T3) to bottom (T1) tertile, increased total WBC, lymphocyte, monocyte and neutrophil counts were associated with higher CVD risk: 1.31 (1.10; 1.55), 1.20 (1.02; 1.41), 1.21 (1.03; 1.41) and 1.24 (1.05; 1.47), as well as mean corpuscular volume (MCV: 1.23 [1.04; 1.46]) and red cell distribution width (RDW: 1.22 [1.03; 1.44]). Platelets displayed an association for count values above the clinically normal range: 1.49 (1.00; 2.22). To conclude, total and differential WBC count, MCV, RDW and platelet count likely play a role in the aetiology of CVD but only WBC provide a modest improvement for the prediction of 10-year CVD risk over traditional CVD risk factors in a general population.
    DOI
    10.1038/s41598-018-21661-x
    PMID
    29459661
    URI
    http://hdl.handle.net/10029/621463
    ae974a485f413a2113503eed53cd6c53
    10.1038/s41598-018-21661-x
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