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    Acute illness from Campylobacter jejuni may require high doses while infection occurs at low doses.

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    Authors
    Teunis, Peter F M
    Bonačić Marinović, Axel
    Tribble, David R
    Porter, Chad K
    Swart, Arno
    Type
    Article
    Language
    en
    
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    Title
    Acute illness from Campylobacter jejuni may require high doses while infection occurs at low doses.
    Published in
    Epidemics 2018; 24:1-20
    Publiekssamenvatting
    Data from a set of different studies on the infectivity and pathogenicity of Campylobacter jejuni were analyzed with a multilevel model, allowing for effects of host species (nonhuman primates and humans) and different strains of the pathogen. All challenge studies involved high doses of the pathogen, resulting in all exposed subjects to become infected. In only one study a dose response effect (increasing trend with dose) for infection was observed. High susceptibility to infection with C. jejuni was found in a joint analysis of outbreaks and challenge studies. For that reason four outbreaks, associated with raw milk consumption, were also included in the present study. The high doses used for inoculation did not cause all infected subjects to develop acute enteric symptoms. The observed outcomes are consistent with a dose response effect for acute symptoms among infected subjects: a conditional illness dose response relation. Nonhuman primates and human volunteers did not appear to have different susceptibilities for developing enteric symptoms, but exposure in outbreaks (raw milk) did lead to a higher probability of symptomatic campylobacteriosis.
    DOI
    10.1016/j.epidem.2018.02.001
    PMID
    29456072
    URI
    http://hdl.handle.net/10029/621465
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.epidem.2018.02.001
    Scopus Count
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