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dc.contributor.authorBarkoff, Alex-Mikael
dc.contributor.authorMertsola, Jussi
dc.contributor.authorPierard, Denis
dc.contributor.authorDalby, Tine
dc.contributor.authorVermedal Hoegh, Silje
dc.contributor.authorGuillot, Sophie
dc.contributor.authorStefanelli, Paola
dc.contributor.authorvan Gent, Marjolein
dc.contributor.authorBerbers, Guy
dc.contributor.authorVestrheim, Didrik F
dc.contributor.authorGreve-Isdahl, Margrethe
dc.contributor.authorWehlin, Lena
dc.contributor.authorLjungman, Margaretha
dc.contributor.authorFry, Norman K
dc.contributor.authorMarkey, Kevin
dc.contributor.authorAuranen, Kari
dc.contributor.authorHe, Qiushui
dc.date.accessioned2018-03-06T08:50:21Z
dc.date.available2018-03-06T08:50:21Z
dc.date.issued2018-02-28
dc.identifier.citationSurveillance of circulating Bordetella pertussis strains in Europe during 1998-2015. 2018 J. Clin. Microbiol.en
dc.identifier.issn1098-660X
dc.identifier.pmid29491017
dc.identifier.doi10.1128/JCM.01998-17
dc.identifier.urihttp://hdl.handle.net/10029/621474
dc.description.abstractOne reason for increased pertussis incidence is the adaptation of Bordetella pertussis to vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV, includes 265 isolates collected from nine European countries during 2012 to 2015 (n=265) and compares the results to previous EUpert I-III studies (1998-2009). The analyses included genotyping, serotyping and pulsed-field gel electrophoresis (PFGE) and multi-locus variable-number tandem repeat analysis (MLVA). Genotyping results showed only small variation among the common virulence genes ofB. pertussisFrequencies of serotypes Fim2 and Fim3 varied among the four collections. Genomic analyses showed that MLVA type 27 increased to 80% between the periods of 1998-2001 and 2012-2015. Two PFGE profiles, BpSR3 (29.4%) and BpSR10 (27.2%), constituted more than 50% of the circulating isolates in the present collection. Our study indicates that the EuropeanB. pertussispopulation is changing more homogenous after the introduction of acellular pertussis vaccines.
dc.language.isoenen
dc.rightsinfo:eu-repo/semantics/closedAccessen
dc.titleSurveillance of circulatingBordetella pertussisstrains in Europe during 1998-2015.en
dc.typeArticleen
dc.identifier.journalJ Clin Microbiol 2018; advance online publication (ahead of print)en
html.description.abstractOne reason for increased pertussis incidence is the adaptation of Bordetella pertussis to vaccine-induced immunity by modulating its genomic structure. This study, EUpert IV, includes 265 isolates collected from nine European countries during 2012 to 2015 (n=265) and compares the results to previous EUpert I-III studies (1998-2009). The analyses included genotyping, serotyping and pulsed-field gel electrophoresis (PFGE) and multi-locus variable-number tandem repeat analysis (MLVA). Genotyping results showed only small variation among the common virulence genes ofB. pertussisFrequencies of serotypes Fim2 and Fim3 varied among the four collections. Genomic analyses showed that MLVA type 27 increased to 80% between the periods of 1998-2001 and 2012-2015. Two PFGE profiles, BpSR3 (29.4%) and BpSR10 (27.2%), constituted more than 50% of the circulating isolates in the present collection. Our study indicates that the EuropeanB. pertussispopulation is changing more homogenous after the introduction of acellular pertussis vaccines.


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