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    DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.

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    Authors
    Walaszczyk, Eliza
    Luijten, Mirjam
    Spijkerman, Annemieke M W
    Bonder, Marc J
    Lutgers, Helen L
    Snieder, Harold
    Wolffenbuttel, Bruce H R
    van Vliet-Ostaptchouk, Jana V
    Type
    Article
    Language
    en
    
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    Title
    DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.
    Published in
    Diabetologia 2018; 61(2):354-68
    Publiekssamenvatting
    Epigenetic mechanisms may play an important role in the aetiology of type 2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels. Here we present a systematic review of these studies and attempt to replicate the CpG sites (CpGs) with the most significant associations from these EWASs in a case-control sample of the Lifelines study.
    DOI
    10.1007/s00125-017-4497-7
    PMID
    29164275
    URI
    http://hdl.handle.net/10029/621562
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00125-017-4497-7
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