DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.

Walaszczyk, Eliza; Luijten, Mirjam; Spijkerman, Annemieke M W; Bonder, Marc J; Lutgers, Helen L; Snieder, Harold; Wolffenbuttel, Bruce H R; van Vliet-Ostaptchouk, Jana V

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Authors

Walaszczyk, Eliza
Luijten, Mirjam
Spijkerman, Annemieke M W
Bonder, Marc J
Lutgers, Helen L
Snieder, Harold
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V

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Article

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Title

DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.

Published in

Diabetologia 2018; 61(2):354-68

Publiekssamenvatting

Epigenetic mechanisms may play an important role in the aetiology of type 2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels. Here we present a systematic review of these studies and attempt to replicate the CpG sites (CpGs) with the most significant associations from these EWASs in a case-control sample of the Lifelines study.