DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.
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Authors
Walaszczyk, ElizaLuijten, Mirjam
Spijkerman, Annemieke M W
Bonder, Marc J
Lutgers, Helen L
Snieder, Harold
Wolffenbuttel, Bruce H R
van Vliet-Ostaptchouk, Jana V
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ArticleLanguage
en
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DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels: a systematic review and replication in a case-control sample of the Lifelines study.Published in
Diabetologia 2018; 61(2):354-68Publiekssamenvatting
Epigenetic mechanisms may play an important role in the aetiology of type 2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1clevels. Here we present a systematic review of these studies and attempt to replicate the CpG sites (CpGs) with the most significant associations from these EWASs in a case-control sample of the Lifelines study.PMID
29164275ae974a485f413a2113503eed53cd6c53
10.1007/s00125-017-4497-7
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