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dc.contributor.authorGrande, Laura
dc.contributor.authorMichelacci, Valeria
dc.contributor.authorBondì, Roslen
dc.contributor.authorGigliucci, Federica
dc.contributor.authorFranz, Eelco
dc.contributor.authorBadouei, Mahdi Askari
dc.contributor.authorSchlager, Sabine
dc.contributor.authorMinelli, Fabio
dc.contributor.authorTozzoli, Rosangela
dc.contributor.authorCaprioli, Alfredo
dc.contributor.authorMorabito, Stefano
dc.date.accessioned2018-03-08T12:36:50Z
dc.date.available2018-03-08T12:36:50Z
dc.date.issued2016
dc.identifier.citationWhole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome. 2016, 22 (12):2078-2086 Emerging Infect. Dis.en
dc.identifier.issn1080-6059
dc.identifier.pmid27584691
dc.identifier.doi10.3201/eid2212.160017
dc.identifier.urihttp://hdl.handle.net/10029/621565
dc.description.abstractVerotoxigenic Escherichia coli infections in humans cause disease ranging from uncomplicated intestinal illnesses to bloody diarrhea and systemic sequelae, such as hemolytic uremic syndrome (HUS). Previous research indicated that pigeons may be a reservoir for a population of verotoxigenic E. coli producing the VT2f variant. We used whole-genome sequencing to characterize a set of VT2f-producing E. coli strains from human patients with diarrhea or HUS and from healthy pigeons. We describe a phage conveying the vtx2f genes and provide evidence that the strains causing milder diarrheal disease may be transmitted to humans from pigeons. The strains causing HUS could derive from VT2f phage acquisition by E. coli strains with a virulence genes asset resembling that of typical HUS-associated verotoxigenic E. coli.
dc.language.isoenen
dc.rightsArchived with thanks to Emerging infectious diseasesen
dc.subject.meshAnimals
dc.subject.meshBacteriophages
dc.subject.meshGenome, Bacterial
dc.subject.meshGenomics
dc.subject.meshHemolytic-Uremic Syndrome
dc.subject.meshHumans
dc.subject.meshPhylogeny
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshSerogroup
dc.subject.meshShiga Toxin 2
dc.subject.meshShiga-Toxigenic Escherichia coli
dc.subject.meshVirulence
dc.subject.meshWhole Genome Sequencing
dc.titleWhole-Genome Characterization and Strain Comparison of VT2f-Producing Escherichia coli Causing Hemolytic Uremic Syndrome.en
dc.typeArticleen
dc.identifier.journalEmerg Infect Dis 2016; 22(12):2078-86en
refterms.dateFOA2018-12-18T14:08:50Z
html.description.abstractVerotoxigenic Escherichia coli infections in humans cause disease ranging from uncomplicated intestinal illnesses to bloody diarrhea and systemic sequelae, such as hemolytic uremic syndrome (HUS). Previous research indicated that pigeons may be a reservoir for a population of verotoxigenic E. coli producing the VT2f variant. We used whole-genome sequencing to characterize a set of VT2f-producing E. coli strains from human patients with diarrhea or HUS and from healthy pigeons. We describe a phage conveying the vtx2f genes and provide evidence that the strains causing milder diarrheal disease may be transmitted to humans from pigeons. The strains causing HUS could derive from VT2f phage acquisition by E. coli strains with a virulence genes asset resembling that of typical HUS-associated verotoxigenic E. coli.


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