Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Jans, JopUnger, Wendy W J
Vissers, Marloes
Ahout, Inge M L
Schreurs, Inge
Wickenhagen, Arthur
de Groot, Ronald
de Jonge, Marien I
Ferwerda, Gerben
Type
ArticleLanguage
en
Metadata
Show full item recordTitle
Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.Published in
Eur J Immunol 2018; 48:621-631Publiekssamenvatting
Interferon gamma (IFN-γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell-cell interactions between monocytes and T cells regulate IFN-γ production. In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants. In vitro, RSV increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited IFN-γ production by adult CD4+T cells. In contrast, IFN-γ production by RSV in newborns was not affected by Siglec-1. The ligand for Siglec-1, CD43, is highly expressed on adult CD4+T cells compared to newborns. Our data show that Siglec-1 reduces IFN-γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec-1-dependent inhibition of IFN-γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.PMID
29266251ae974a485f413a2113503eed53cd6c53
10.1002/eji.201747161
Scopus Count
Collections