Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.
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Authors
Jans, JopUnger, Wendy W J
Vissers, Marloes
Ahout, Inge M L
Schreurs, Inge
Wickenhagen, Arthur
de Groot, Ronald
de Jonge, Marien I
Ferwerda, Gerben
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ArticleLanguage
en
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Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.Published in
Eur J Immunol 2018; 48:621-631Publiekssamenvatting
Interferon gamma (IFN-γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell-cell interactions between monocytes and T cells regulate IFN-γ production. In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants. In vitro, RSV increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited IFN-γ production by adult CD4+T cells. In contrast, IFN-γ production by RSV in newborns was not affected by Siglec-1. The ligand for Siglec-1, CD43, is highly expressed on adult CD4+T cells compared to newborns. Our data show that Siglec-1 reduces IFN-γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec-1-dependent inhibition of IFN-γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.PMID
29266251ae974a485f413a2113503eed53cd6c53
10.1002/eji.201747161
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