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    Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.

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    Authors
    Jans, Jop
    Unger, Wendy W J
    Vissers, Marloes
    Ahout, Inge M L
    Schreurs, Inge
    Wickenhagen, Arthur
    de Groot, Ronald
    de Jonge, Marien I
    Ferwerda, Gerben
    Type
    Article
    Language
    en
    
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    Title
    Siglec-1 inhibits RSV-induced interferon gamma production by adult T cells in contrast to newborn T cells.
    Published in
    Eur J Immunol 2018; 48:621-631
    Publiekssamenvatting
    Interferon gamma (IFN-γ) plays an important role in the antiviral immune response during respiratory syncytial virus (RSV) infections. Monocytes and T cells are recruited to the site of RSV infection, but it is unclear whether cell-cell interactions between monocytes and T cells regulate IFN-γ production. In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants. In vitro, RSV increased expression of Siglec-1 on healthy newborn and adult monocytes. RSV-induced Siglec-1 on monocytes inhibited IFN-γ production by adult CD4+T cells. In contrast, IFN-γ production by RSV in newborns was not affected by Siglec-1. The ligand for Siglec-1, CD43, is highly expressed on adult CD4+T cells compared to newborns. Our data show that Siglec-1 reduces IFN-γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec-1-dependent inhibition of IFN-γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood.
    DOI
    10.1002/eji.201747161
    PMID
    29266251
    URI
    http://hdl.handle.net/10029/621613
    ae974a485f413a2113503eed53cd6c53
    10.1002/eji.201747161
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