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    Enhanced Bordetella pertussisacquisition rate in adolescents during the 2012 epidemic in the Netherlands and evidence for prolonged antibody persistence after infection.

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    Authors
    van der Lee, Saskia
    Stoof, Susanne P
    van Ravenhorst, Mariette B
    van Gageldonk, Pieter G M
    van der Maas, Nicoline A T
    Sanders, Elisabeth A M
    Buisman, Anne-Marie
    Berbers, Guy A M
    Type
    Article
    Language
    en
    
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    Title
    Enhanced Bordetella pertussisacquisition rate in adolescents during the 2012 epidemic in the Netherlands and evidence for prolonged antibody persistence after infection.
    Published in
    Euro Surveill 2017; 22(47); 22(47):17-00011
    Publiekssamenvatting
    IntroductionIn 2012 a large epidemic of pertussis occurred in the Netherlands. We assessed pertussis toxin (PT) antibody levels in longitudinal serum samples from Dutch 10-18 year-olds, encompassing the epidemic, to investigate pertussis infection incidence.Methods: Blood was sampled in October 2011 (n = 239 adolescents), then 1 year (2012; n = 228) and 3 years (2014; n = 167) later. PT-IgG concentrations were measured by immunoassay and concentrations ≥50 IU/mL (seropositive) assumed indicative of an infection within the preceding year.Results: During the 2012 epidemic, 10% of participants became seropositive, while this was just 3% after the epidemic. The pertussis acquisition rate proved to be sixfold higher during the epidemic (97 per 1,000 person-years) compared with 2012-2014 (16 per 1,000 person-years). In 2012, pertussis notifications among adolescents nationwide were 228/100,000 (0.23%), which is at least 40 times lower than the seropositivity percentage. Remarkably, 17 of the 22 seropositive participants in 2011, were still seropositive in 2012 and nine remained seropositive for at least 3 years.Discussion: Longitudinal studies allow a better estimation of pertussis infections in the population. A PT-IgG concentration ≥50 IU/mL as indication of recent infection may overestimate these numbers in cross-sectional serosurveillance and should be used carefully.
    DOI
    10.2807/1560-7917.ES.2017.22.47.17-00011
    PMID
    29183555
    URI
    http://hdl.handle.net/10029/621623
    ae974a485f413a2113503eed53cd6c53
    10.2807/1560-7917.ES.2017.22.47.17-00011
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