Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
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Authors
van Duijnhoven, Fränzel J BJenab, Mazda
Hveem, Kristian
Siersema, Peter D
Fedirko, Veronika
Duell, Eric J
Kampman, Ellen
Halfweeg, Anouk
van Kranen, Henk J
van den Ouweland, Jody M W
Weiderpass, Elisabete
Murphy, Neil
Langhammer, Arnulf
Ness-Jensen, Eivind
Olsen, Anja
Tjønneland, Anne
Overvad, Kim
Cadeau, Claire
Kvaskoff, Marina
Boutron-Ruault, Marie-Christine
Katzke, Verena A
Kühn, Tilman
Boeing, Heiner
Trichopoulou, Antonia
Kotanidou, Anastasia
Kritikou, Maria
Palli, Domenico
Agnoli, Claudia
Tumino, Rosario
Panico, Salvatore
Matullo, Giuseppe
Peeters, Petra
Brustad, Magritt
Olsen, Karina Standahl
Lasheras, Cristina
Obón-Santacana, Mireia
Sánchez, María-José
Dorronsoro, Miren
Chirlaque, Maria-Dolores
Barricarte, Aurelio
Manjer, Jonas
Almquist, Martin
Renström, Frida
Ye, Weimin
Wareham, Nick
Khaw, Kay-Tee
Bradbury, Kathryn E
Freisling, Heinz
Aune, Dagfinn
Norat, Teresa
Riboli, Elio
Bueno-de-Mesquita, H B As
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ArticleLanguage
en
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Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.Published in
Int J Cancer 2018; 142(6):1189-1201Publiekssamenvatting
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2and 25(OH)D3combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.PMID
29114875ae974a485f413a2113503eed53cd6c53
10.1002/ijc.31146
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