Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort.
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Authors
Fortner, Renée TSchock, Helena
Le Cornet, Charlotte
Hüsing, Anika
Vitonis, Allison F
Johnson, Theron S
Fichorova, Raina N
Fashemi, Titilayo
Yamamoto, Hidemi S
Tjønneland, Anne
Hansen, Louise
Overvad, Kim
Boutron-Ruault, Marie-Christine
Kvaskoff, Marina
Severi, Gianluca
Boeing, Heiner
Trichopoulou, Antonia
Papatesta, Eleni-Maria
La Vecchia, Carlo
Palli, Domenico
Sieri, Sabina
Tumino, Rosario
Sacerdote, Carlotta
Mattiello, Amalia
Onland-Moret, N Charlotte
Peeters, Petra H
Bueno-de-Mesquita, H B As
Weiderpass, Elisabete
Quirós, J Ramón
Duell, Eric J
Sánchez, Maria-Jose
Navarro, Carmen
Ardanaz, Eva
Larrañaga, Nerea
Nodin, Björn
Jirström, Karin
Idahl, Annika
Lundin, Eva
Khaw, Kay-Tee
Travis, Ruth C
Gunter, Marc
Johansson, Mattias
Dossus, Laure
Merritt, Melissa A
Riboli, Elio
Terry, Kathryn L
Cramer, Daniel W
Kaaks, Rudolf
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ArticleLanguage
en
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Ovarian cancer early detection by circulating CA125 in the context of anti-CA125 autoantibody levels: Results from the EPIC cohort.Published in
Int J Cancer 2018; 142(7):1355-60Publiekssamenvatting
CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non-cases. Anti-CA125 autoantibodies are observed in circulation. Our objective was to evaluate whether these antibodies (1) can serve as early detection markers, providing evidence of an immune response to a developing tumor, and (2) modify the discriminatory capacity of CA125 by either masking CA125 levels (resulting in lower discrimination) or acting synergistically to improve discrimination between cases and non-cases. We investigated these objectives using a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (EPIC) including 250 cases diagnosed within 4 years of blood collection and up to four matched controls. Circulating CA125 antigen and antibody levels were quantified using an electrochemiluminescence assay. Adjusted areas under the curve (aAUCs) by 2-year lag-time intervals were calculated using conditional logistic regression calibrated toward the absolute risk estimates from a pre-existing epidemiological risk model as an offset-variable. Anti-CA125 levels alone did not discriminate cases from controls. For cases diagnosed <2 years after blood collection, discrimination by CA125 antigen was suggestively higher with higher anti-CA125 levels (aAUC, highest antibody tertile: 0.84 [0.76-0.92]; lowest tertile: 0.76 [0.67-0.86]; phet = 0.06). We provide the first evidence of potentially synergistic discrimination effects of CA125 and anti-CA125 antibodies in ovarian early detection. If these findings are replicated, evaluating CA125 in the context of its antibody may improve ovarian cancer early detection.PMID
29159934ae974a485f413a2113503eed53cd6c53
10.1002/ijc.31164
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