A Novel Experimental and Modelling Strategy for Nanoparticle Toxicity Testing Enabling the Use of Small Quantities.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Type
ArticleLanguage
en
Metadata
Show full item recordTitle
A Novel Experimental and Modelling Strategy for Nanoparticle Toxicity Testing Enabling the Use of Small Quantities.Published in
Int J Environ Res Public Health 2017; 14(11):e1348Publiekssamenvatting
Metallic nanoparticles (NPs) differ from other metal forms with respect to their large surface to volume ratio and subsequent inherent reactivity. Each new modification to a nanoparticle alters the surface to volume ratio, fate and subsequently the toxicity of the particle. Newly-engineered NPs are commonly available only in low quantities whereas, in general, rather large amounts are needed for fate characterizations and effect studies. This challenge is especially relevant for those NPs that have low inherent toxicity combined with low bioavailability. Therefore, within our study, we developed new testing strategies that enable working with low quantities of NPs. The experimental testing method was tailor-made for NPs, whereas we also developed translational models based on different dose-metrics allowing to determine dose-response predictions for NPs. Both the experimental method and the predictive models were verified on the basis of experimental effect data collected using zebrafish embryos exposed to metallic NPs in a range of different chemical compositions and shapes. It was found that the variance in the effect data in the dose-response predictions was best explained by the minimal diameter of the NPs, whereas the data confirmed that the predictive model is widely applicable to soluble metallic NPs. The experimental and model approach developed in our study support the development of (eco)toxicity assays tailored to nano-specific features.PMID
29113114ae974a485f413a2113503eed53cd6c53
10.3390/ijerph14111348
Scopus Count
Collections
Related articles
- Dose metrics assessment for differently shaped and sized metal-based nanoparticles.
- Authors: Hua J, Vijver MG, Chen G, Richardson MK, Peijnenburg WJ
- Issue date: 2016 Oct
- Physiological effects of nanoparticles on fish: a comparison of nanometals versus metal ions.
- Authors: Shaw BJ, Handy RD
- Issue date: 2011 Aug
- Developmental toxicity of glycine-coated silica nanoparticles in embryonic zebrafish.
- Authors: Dumitrescu E, Karunaratne DP, Prochaska MK, Liu X, Wallace KN, Andreescu S
- Issue date: 2017 Oct
- Particle-specific toxic effects of differently shaped zinc oxide nanoparticles to zebrafish embryos (Danio rerio).
- Authors: Hua J, Vijver MG, Richardson MK, Ahmad F, Peijnenburg WJ
- Issue date: 2014 Dec
- Assessing the potential risks to zebrafish posed by environmentally relevant copper and silver nanoparticles.
- Authors: Chio CP, Chen WY, Chou WC, Hsieh NH, Ling MP, Liao CM
- Issue date: 2012 Mar 15