Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

Aleksandrova, Krasimira; Jenab, Mazda; Leitzmann, Michael; Bueno-de-Mesquita, Bas; Kaaks, Rudolf; Trichopoulou, Antonia; Bamia, Christina; Lagiou, Pagona; Rinaldi, Sabina; Freisling, Heinz; Carayol, Marion; Pischon, Tobias; Drogan, Dagmar; Weiderpass, Elisabete; Jakszyn, Paula; Overvad, Kim; Dahm, Christina C; Tjønneland, Anne; Bouton-Ruault, Marie-Christine; Kühn, Tilman; Peppa, Eleni; Valanou, Elissavet; La Vecchia, Carlo; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Agnoli, Claudia; Tumino, Rosario; May, Anne; van Vulpen, Jonna; Benjaminsen Borch, Kristin; Oluwafemi Oyeyemi, Sunday; Quirós, J Ramón; Bonet, Catalina; Sánchez, María-José; Dorronsoro, Miren; Navarro, Carmen; Barricarte, Aurelio; van Guelpen, Bethany; Wennberg, Patrik; Key, Timothy J; Khaw, Kay-Tee; Wareham, Nicholas; Assi, Nada; Ward, Heather A; Aune, Dagfinn; Riboli, Elio; Boeing, Heiner

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Title

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

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Int J Epidemiol 2017; 46(6):1823-35

Publiekssamenvatting

There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.