Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study.
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Authors
Naudin, SabineLi, Kuanrong
Jaouen, Tristan
Assi, Nada
Kyrø, Cecilie
Tjønneland, Anne
Overvad, Kim
Boutron-Ruault, Marie-Christine
Rebours, Vinciane
Védié, Anne-Laure
Boeing, Heiner
Kaaks, Rudolf
Katzke, Verena
Bamia, Christina
Naska, Androniki
Trichopoulou, Antonia
Berrino, Franco
Tagliabue, Giovanna
Palli, Domenico
Panico, Salvatore
Tumino, Rosario
Sacerdote, Carlotta
Peeters, Petra H
Bueno-de-Mesquita, Bas
Weiderpass Vainio, Elisabete
Gram, Inger Torhild
Skeie, Guri
Chirlaque, Maria-Dolores
Rodríguez-Barranco, Miguel
Barricarte, Aurelio
Quirós, Jose Ramón
Dorronsoro, Miren
Johansson, Ingegerd
Sund, Malin
Sternby, Hanna
Bradbury, Kathryn E
Wareham, Nick
Riboli, Elio
Gunter, Marc
Brennan, Paul
Duell, Eric J
Ferrari, Pietro
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ArticleLanguage
en
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Lifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study.Published in
Int J Cancer 2018; advance online publication (ahead of print)Publiekssamenvatting
Recent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In this study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. This article is protected by copyright. All rights reserved.PMID
29524225ae974a485f413a2113503eed53cd6c53
10.1002/ijc.31367
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