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dc.contributor.authorNaudin, Sabine
dc.contributor.authorLi, Kuanrong
dc.contributor.authorJaouen, Tristan
dc.contributor.authorAssi, Nada
dc.contributor.authorKyrø, Cecilie
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorRebours, Vinciane
dc.contributor.authorVédié, Anne-Laure
dc.contributor.authorBoeing, Heiner
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKatzke, Verena
dc.contributor.authorBamia, Christina
dc.contributor.authorNaska, Androniki
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorBerrino, Franco
dc.contributor.authorTagliabue, Giovanna
dc.contributor.authorPalli, Domenico
dc.contributor.authorPanico, Salvatore
dc.contributor.authorTumino, Rosario
dc.contributor.authorSacerdote, Carlotta
dc.contributor.authorPeeters, Petra H
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorWeiderpass Vainio, Elisabete
dc.contributor.authorGram, Inger Torhild
dc.contributor.authorSkeie, Guri
dc.contributor.authorChirlaque, Maria-Dolores
dc.contributor.authorRodríguez-Barranco, Miguel
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorQuirós, Jose Ramón
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorSund, Malin
dc.contributor.authorSternby, Hanna
dc.contributor.authorBradbury, Kathryn E
dc.contributor.authorWareham, Nick
dc.contributor.authorRiboli, Elio
dc.contributor.authorGunter, Marc
dc.contributor.authorBrennan, Paul
dc.contributor.authorDuell, Eric J
dc.contributor.authorFerrari, Pietro
dc.date.accessioned2018-03-22T11:59:54Z
dc.date.available2018-03-22T11:59:54Z
dc.date.issued2018-03-09
dc.identifier.citationLifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study. 2018 Int. J. Canceren
dc.identifier.issn1097-0215
dc.identifier.pmid29524225
dc.identifier.doi10.1002/ijc.31367
dc.identifier.urihttp://hdl.handle.net/10029/621684
dc.description.abstractRecent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In this study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. This article is protected by copyright. All rights reserved.
dc.language.isoenen
dc.rightsArchived with thanks to International journal of canceren
dc.titleLifetime and baseline alcohol intakes and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition study.en
dc.typeArticleen
dc.identifier.journalInt J Cancer 2018; advance online publication (ahead of print)en
html.description.abstractRecent evidence suggested a weak relationship between alcohol consumption and pancreatic cancer (PC) risk. In this study, the association between lifetime and baseline alcohol intakes and the risk of PC was evaluated, including the type of alcoholic beverages and potential interaction with smoking. Within the European Prospective Investigation into Cancer and Nutrition (EPIC) study, 1,283 incident PC (57% women) were diagnosed from 476,106 cancer-free participants, followed up for 14 years. Amounts of lifetime and baseline alcohol were estimated through lifestyle and dietary questionnaires, respectively. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and their 95% confidence interval (CI). Alcohol intake was positively associated with PC risk in men. Associations were mainly driven by extreme alcohol levels, with HRs comparing heavy drinkers (>60 g/day) to the reference category (0.1-4.9 g/day) equal to 1.77 (95% CI: 1.06, 2.95) and 1.63 (95% CI: 1.16, 2.29) for lifetime and baseline alcohol, respectively. Baseline alcohol intakes from beer (>40 g/day) and spirits/liquors (>10 g/day) showed HRs equal to 1.58 (95% CI: 1.07, 2.34) and 1.41 (95% CI: 1.03, 1.94), respectively, compared to the reference category (0.1-2.9 g/day). In women, HR estimates did not reach statistically significance. The alcohol and PC risk association was not modified by smoking status. Findings from a large prospective study suggest that baseline and lifetime alcohol intakes were positively associated with PC risk, with more apparent risk estimates for beer and spirits/liquors than wine intake. This article is protected by copyright. All rights reserved.


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