Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Gonos, Efstathios S
Dollé, Martijn E T
MetadataShow full item record
TitleZinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project.
Published inJ Gerontol A Biol Sci Med Sci 2018; advance online publication (ahead of print)
PubliekssamenvattingMetallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO). We found that the lymphocyte capability to induce MT in response to Zn is not affected by aging. However, GO participants showed lower Zn-induced MT and increased basal expression of MT1A, MT1X and ZnT-1 genes than RASIG subjects. Moreover, Zn-induced MT levels were found to be inversely related with oxidative stress markers (plasma protein carbonyls, 3-nitrotyrosine and malondialdehyde) in the whole population, but not in GO subjects.In conclusion, our results support the hypothesis that the response to Zn is attenuated in PBMCs of centenarian offspring compared to the general population as a consequence of a tighter control of Zn homeostasis which is likely to provide them constant protection against stress stimuli over the whole lifespan.
- Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply.
- Authors: Mocchegiani E, Giacconi R, Cipriano C, Gasparini N, Orlando F, Stecconi R, Muzzioli M, Isani G, Carpenè E
- Issue date: 2002 Mar 31
- Property of metallothionein as a Zn pool differs depending on the induced condition of metallothionein.
- Authors: Kondoh M, Imada N, Kamada K, Tsukahara R, Higashimoto M, Takiguchi M, Watanabe Y, Sato M
- Issue date: 2003 Apr 30
- Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein.
- Authors: St Croix CM, Wasserloos KJ, Dineley KE, Reynolds IJ, Levitan ES, Pitt BR
- Issue date: 2002 Feb
- Protective role of zinc-metallothionein (Zn-MT) in iron nitrilotriacetate (Fe-NTA)-induced renal oxidative damage.
- Authors: Iqbal M, Noor R, Mizuno R, Okada S
- Issue date: 2003
- Rat hepatocytes with elevated metallothionein expression are resistant to N-methyl-N'-nitro-N-nitrosoguanidine cytotoxicity.
- Authors: Moffatt P, Plaa GL, Denizeau F
- Issue date: 1996 Jan