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    Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project.

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    Authors
    Giacconi, Robertina
    Costarelli, Laura
    Piacenza, Francesco
    Basso, Andrea
    Bürkle, Alexander
    Moreno-Villanueva, Maria
    Grune, Tilman
    Weber, Daniela
    Stuetz, Wolfgang
    Gonos, Efstathios S
    Schön, Christiane
    Grubeck-Loebenstein, Beatrix
    Sikora, Ewa
    Toussaint, Olivier
    Debacq-Chainiaux, Florence
    Franceschi, Claudio
    Hervonen, Antti
    Slagboom, Eline
    Ciccarone, Fabio
    Zampieri, Michele
    Caiafa, Paola
    Jansen, Eugène
    Dollé, Martijn E T
    Breusing, Nicolle
    Mocchegiani, Eugenio
    Malavolta, Marco
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    Type
    Article
    Language
    en
    
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    Title
    Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project.
    Published in
    J Gerontol A Biol Sci Med Sci 2018; advance online publication (ahead of print)
    Publiekssamenvatting
    Metallothionein (MT) family are cysteine-rich proteins that regulate zinc (Zn) homeostasis and protect against oxidative damage. Studies in transgenic mice have shown that MT favourably influence longevity, although their role in human aging is not completely understood.Within the European multicenter study MARK-AGE, we analysed MT induction after Zn treatment in peripheral blood mononuclear cells (PBMCs) and its relation with redox biomarkers in 2936 age-stratified subjects (35-75 years) including the general population (RASIG), centenarian offspring (GO) and their spouses (SGO). We found that the lymphocyte capability to induce MT in response to Zn is not affected by aging. However, GO participants showed lower Zn-induced MT and increased basal expression of MT1A, MT1X and ZnT-1 genes than RASIG subjects. Moreover, Zn-induced MT levels were found to be inversely related with oxidative stress markers (plasma protein carbonyls, 3-nitrotyrosine and malondialdehyde) in the whole population, but not in GO subjects.In conclusion, our results support the hypothesis that the response to Zn is attenuated in PBMCs of centenarian offspring compared to the general population as a consequence of a tighter control of Zn homeostasis which is likely to provide them constant protection against stress stimuli over the whole lifespan.
    DOI
    10.1093/gerona/glx192
    PMID
    29045571
    URI
    http://hdl.handle.net/10029/621694
    ae974a485f413a2113503eed53cd6c53
    10.1093/gerona/glx192
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