Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection.

van Beek, Janko; de Graaf, Miranda; Smits, Saskia; Schapendonk, Claudia M E; Verjans, Georges M G M; Vennema, Harry; van der Eijk, Annemiek A; Phan, My V T; Cotten, Matthew; Koopmans, Marion

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Authors

van Beek, Janko
de Graaf, Miranda
Smits, Saskia
Schapendonk, Claudia M E
Verjans, Georges M G M
Vennema, Harry
van der Eijk, Annemiek A
Phan, My V T
Cotten, Matthew
Koopmans, Marion

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Article

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Title

Whole-Genome Next-Generation Sequencing to Study Within-Host Evolution of Norovirus (NoV) Among Immunocompromised Patients With Chronic NoV Infection.

Published in

J Infect Dis 2017; 216(12):1513-24

Publiekssamenvatting

The genus Norovirus comprises large genetic diversity, and new GII.4 variants emerge every 2-3 years. It is unknown in which host these new variants originate. Here we study whether prolonged shedders within the immunocompromised population could be a reservoir for newly emerging strains.