Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.
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Authors
Assi, NadaThomas, Duncan C
Leitzman, Michael
Stepien, Magdalena
Chajes, Veronique
Philip, Thierry
Vineis, Paolo
Bamia, Christina
Boutron-Ruault, Marie-Christine
Sandanger, Torkjel M
Molinuevo, Amaia
Boshuizen, Hendriek C
Sundkvist, Anneli
Kühn, Tilman
Travis, Ruth C
Overvad, Kim
Riboli, Elio
Gunter, Marc J
Scalbert, Augustin
Jenab, Mazda
Ferrari, Pietro
Viallon, Vivian
Type
ArticleLanguage
en
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Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.Published in
Cancer Epidemiol Biomarkers Prev 2018; 27(5):531-40Publiekssamenvatting
The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within EPIC where healthy lifestyle index (HLI) variables were related to targeted serum metabolites.PMID
29563134ae974a485f413a2113503eed53cd6c53
10.1158/1055-9965.EPI-17-0649
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