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    Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.

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    Authors
    Assi, Nada
    Thomas, Duncan C
    Leitzman, Michael
    Stepien, Magdalena
    Chajes, Veronique
    Philip, Thierry
    Vineis, Paolo
    Bamia, Christina
    Boutron-Ruault, Marie-Christine
    Sandanger, Torkjel M
    Molinuevo, Amaia
    Boshuizen, Hendriek C
    Sundkvist, Anneli
    Kühn, Tilman
    Travis, Ruth C
    Overvad, Kim
    Riboli, Elio
    Gunter, Marc J
    Scalbert, Augustin
    Jenab, Mazda
    Ferrari, Pietro
    Viallon, Vivian
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    Type
    Article
    Language
    en
    
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    Title
    Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC.
    Published in
    Cancer Epidemiol Biomarkers Prev 2018; 27(5):531-40
    Publiekssamenvatting
    The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within EPIC where healthy lifestyle index (HLI) variables were related to targeted serum metabolites.
    DOI
    10.1158/1055-9965.EPI-17-0649
    PMID
    29563134
    URI
    http://hdl.handle.net/10029/621704
    ae974a485f413a2113503eed53cd6c53
    10.1158/1055-9965.EPI-17-0649
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